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Literature DB >> 19007655

Estrogen and progestogen therapy in postmenopausal women.

Abstract

This Educational Bulletin discusses the effectiveness of hormone therapy (HT) for relieving vasomotor and urogenital symptoms and the side effects associated with such treatment; considers the evidence concerning the effects of HT on the risk of osteoporosis and related fractures and on the risks of coronary artery disease, dementia, and colorectal cancer; and considers the longer term effects of HT on the risks of stroke, venous thromboembolism, and cancer of the breast, endometrium, and ovary.

Entities: Disease Species

Mesh：

Substances：
Estrogens
Progestins

Year: 2008 PMID： 19007655 DOI： 10.1016/j.fertnstert.2008.08.091

Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329

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Cited

7 in total

1. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.

Authors: Namrata Bali; Jason M Arimoto; Nahoko Iwata; Sharon W Lin; Liqin Zhao; Roberta D Brinton; Todd E Morgan; Caleb E Finch
Journal: Endocrinology Date: 2011-12-06 Impact factor: 4.736

2. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

Authors: Carolyn D DuSell; Erik R Nelson; Xiaojuan Wang; Jennifer Abdo; Ulrike I Mödder; Michihisa Umetani; Diane Gesty-Palmer; Norman B Javitt; Sundeep Khosla; Donald P McDonnell
Journal: Endocrinology Date: 2010-05-25 Impact factor: 4.736

Estrogen and progestogen therapy in postmenopausal women.

1. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.

2. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

3. Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias.

4. Sex hormone drives blood stem cell reproduction.

5. Estrogen plus progestin and colorectal cancer incidence and mortality.

6. Combined hormone therapy at menopause and breast cancer: a warning--short-term use increases risk.

7. Guidelines and recommendations on hormone therapy in the menopause.