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Literature DB >> 19007176

Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete.

Chollaratt Boonlarppradab¹, Christopher A Kauffman, Paul R Jensen, William Fenical.

Abstract

Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 microM for marineosin A) and selective activities in diverse cancer cell types.

Entities: CellLine Chemical Disease Species

Mesh：

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Year: 2008 PMID： 19007176 PMCID： PMC2654761 DOI： 10.1021/ol8020644

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

6 in total

Review 1. Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years.

Authors: Alois Fürstner
Journal: Angew Chem Int Ed Engl Date: 2003-08-11 Impact factor: 15.336

Review 2. Bioactive microbial metabolites.

Authors: János Bérdy
Journal: J Antibiot (Tokyo) Date: 2005-01 Impact factor: 2.649

3. Developing a new resource for drug discovery: marine actinomycete bacteria.

Authors: William Fenical; Paul R Jensen
Journal: Nat Chem Biol Date: 2006-12 Impact factor: 15.040

4. Phylogenetic diversity of gram-positive bacteria cultured from marine sediments.

Authors: Erin A Gontang; William Fenical; Paul R Jensen
Journal: Appl Environ Microbiol Date: 2007-03-30 Impact factor: 4.792

5. Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae.

Authors: Luis A Maldonado; William Fenical; Paul R Jensen; Christopher A Kauffman; Tracy J Mincer; Alan C Ward; Alan T Bull; Michael Goodfellow
Journal: Int J Syst Evol Microbiol Date: 2005-09 Impact factor: 2.747

6. Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera.

Authors: X Shen; T L Perry; C D Dunbar; M Kelly-Borges; M T Hamann
Journal: J Nat Prod Date: 1998-10 Impact factor: 4.050

6 in total

20 in total

Review 1. Oxidative Cyclization in Natural Product Biosynthesis.

Authors: Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal: Chem Rev Date: 2016-12-12 Impact factor: 60.622

2. RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4'-Methoxy-2,2'-Bipyrrole-5'-Carbaldehyde.

Authors: Qingshan Long; Daniel E Jeffries; Shuangjun Lin; Xuefei Chen; Weijun He; Yemin Wang; Zixin Deng; Craig W Lindsley; Meifeng Tao
Journal: Appl Environ Microbiol Date: 2020-01-07 Impact factor: 4.792

3. Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis.

Authors: Sang-Jip Nam; Susana P Gaudêncio; Christopher A Kauffman; Paul R Jensen; Tamara P Kondratyuk; Laura E Marler; John M Pezzuto; William Fenical
Journal: J Nat Prod Date: 2010-06-25 Impact factor: 4.050

4. Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model.

Authors: Leslie N Aldrich; Cynthia B Berry; Brittney S Bates; Leah C Konkol; Miranda So; Craig W Lindsley
Journal: European J Org Chem Date: 2013-07-01

5. MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway.

Authors: Wanli Lu; Papireddy Kancharla; Kevin A Reynolds
Journal: Org Lett Date: 2017-03-08 Impact factor: 6.005