| Literature DB >> 19006672 |
Bradley A Scates1, Bethany L Lashbrook, Benjamin C Chastain, Kaoru Tominaga, Brandon T Elliott, Nicholas J Theising, Thomas A Baker, Richard W Fitch.
Abstract
A homologous series of polyethylene glycol (PEG) monomethyl ethers were conjugated with three ligand series for nicotinic acetylcholine receptors. Conjugates of acetylaminocholine, the cyclic analog 1-acetyl-4,4-dimethylpiperazinium, and pyridyl ether A-84543 were prepared. Each series was found to retain significant affinity at nicotinic receptors in rat cerebral cortex with tethers of up to six PEG units. Such compounds are hydrophilic ligands which may serve as models for fluorescent/affinity probes and multivalent ligands for nAChR.Entities:
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Year: 2008 PMID： 19006672 PMCID： PMC2903455 DOI： 10.1016/j.bmc.2008.10.045
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641