Literature DB >> 19006368

Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones.

Rui Zhang1, Dingyuan Zhang, Yongli Guo, Guangyuan Zhou, Zijiang Jiang, Dewen Dong.   

Abstract

A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.

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Year:  2008        PMID： 19006368     DOI： 10.1021/jo801959j

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  A Stereodivergent Approach for Accessing Both C2,8a-Syn and C2,8a-Anti Relative Stereochemical Manifolds in the Lepadin Family via a TiCL(4)-Promoted Aza-[3 + 3] Annulation.

Authors:  Gang Li; Lauren J Carlson; Irina K Sagamanova; Brian W Slafer; Richard P Hsung; Claudio Gilardi; Heather M Sklenicka; Nadiya Sydroenko
Journal:  Synthesis (Stuttg)       Date:  2009-09-01       Impact factor: 3.157

2.  An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide.

Authors:  Liquan Tan; Peng Zhou; Cui Chen; Weibing Liu
Journal:  Beilstein J Org Chem       Date:  2013-11-28       Impact factor: 2.883
  2 in total

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