Literature DB >> 19005586

Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid.

René Martin1, Frank Däbritz, Eugeni V Entchev, Teymuras V Kurzchalia, Hans-Joachim Knölker.   

Abstract

We report a stereoselective synthesis of the (25S)-cholestenoic-26-acids which are highly efficient ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.

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Year:  2008        PMID： 19005586     DOI： 10.1039/b815064h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

1.  A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.

Authors:  Joshua C Judkins; Parag Mahanti; Jacob B Hoffman; Isaiah Yim; Adam Antebi; Frank C Schroeder
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-22       Impact factor: 15.336

2.  Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans.

Authors:  Sider Penkov; Damla Kaptan; Cihan Erkut; Mihail Sarov; Fanny Mende; Teymuras V Kurzchalia
Journal:  Nat Commun       Date:  2015-08-20       Impact factor: 14.919

3.  Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids.

Authors:  David P Brownholland; Douglas F Covey
Journal:  Steroids       Date:  2017-03-12       Impact factor: 2.668

4.  Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.

Authors:  Kamalesh K Sharma; Zhu Wang; Daniel L Motola; Carolyn L Cummins; David J Mangelsdorf; Richard J Auchus
Journal:  Mol Endocrinol       Date:  2009-02-05

5.  DAF-12 regulates a connected network of genes to ensure robust developmental decisions.

Authors:  Daniel Hochbaum; Yue Zhang; Carsten Stuckenholz; Paul Labhart; Vassili Alexiadis; René Martin; Hans-Joachim Knölker; Alfred L Fisher
Journal:  PLoS Genet       Date:  2011-07-21       Impact factor: 5.917

6.  No Significant Increase in the Δ4- and Δ7-Dafachronic Acid Concentration in the Long-Lived glp-1 Mutant, nor in the Mutants Defective in Dauer Formation.

Authors:  Tie-Mei Li; Weilong Liu; Shan Lu; Yan-Ping Zhang; Le-Mei Jia; Jie Chen; Xiangke Li; Xiaoguang Lei; Meng-Qiu Dong
Journal:  G3 (Bethesda)       Date:  2015-05-12       Impact factor: 3.154

7.  Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.

Authors:  Feng Liu; Chen-Xi He; Li-Jun Luo; Quan-Li Zou; Yong-Xu Zhao; Ratni Saini; San-Feng Han; Hans-Joachim Knölker; Li-Shun Wang; Bao-Xue Ge
Journal:  PLoS Pathog       Date:  2013-08-22       Impact factor: 6.823

8.  Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves.

Authors:  Celina Galles; Gastón M Prez; Sider Penkov; Sebastian Boland; Exequiel O J Porta; Silvia G Altabe; Guillermo R Labadie; Ulrike Schmidt; Hans-Joachim Knölker; Teymuras V Kurzchalia; Diego de Mendoza
Journal:  Sci Rep       Date:  2018-04-23       Impact factor: 4.379
  8 in total

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