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Literature DB >> 19005236

The polymorphisms of bovine cocaine- and amphetamine-regulated transcripts and their associations with cattle (Bos taurus) growth traits.

Chun Lei Zhang¹, Hong Chen, Yan Hong Wang, Xian Yong Lan, Chu Zhao Lei, Xing Tang Fang.

Abstract

We investigated the polymorphisms of bovine cocaine- and amphetamine-regulated transcripts (CART ). The coding and regulating regions of CART were screened in 7 cattle breeds by the single-stranded conformation polymorphism (SSCP) technique. The four loci (C1,C2, C3 and C4) studied were all polymorphic. Polymerase chain reaction (PCR) products representing different SSCP variants were sequenced and a total of 9 single-nucleotide polymorphisms (SNPs) were found. The associations between polymorphic loci and the growth traits of Nanyang cattle were analysed. The results indicated that genotype A1A1 of the C1 locus was associated with a higher body weight (P less than 0.05) than heterozygous A1B1. Genotype A2A2 of the C2 locus was associated with lower body weight and average daily weight gain (P < or = 0.001) than heterozygous A2B2. C3 and C4 loci had no significant effect on Nanyang cattle growth traits (P > 0.05).

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 19005236 DOI： 10.1007/s12038-008-0056-1

Source DB: PubMed Journal: J Biosci ISSN： 0250-5991 Impact factor: 1.826

16 in total

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2. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight.

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Journal: Regul Pept Date: 2005-07-15

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Journal: J Neurosci Date: 1995-03 Impact factor: 6.167

4. Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters.

Authors: J G Mercer; K M Moar; T J Logie; P A Findlay; C L Adam; P J Morgan
Journal: Endocrinology Date: 2001-10 Impact factor: 4.736

5. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland.

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Journal: J Neuroendocrinol Date: 1997-11 Impact factor: 3.627

6. Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system.

Authors: T Okumura; H Yamada; W Motomura; Y Kohgo
Journal: Endocrinology Date: 2000-08 Impact factor: 4.736

7. Single base-pair substitutions in exon-intron junctions of human genes: nature, distribution, and consequences for mRNA splicing.

Authors: Michael Krawczak; Nick S T Thomas; Bernd Hundrieser; Matthew Mort; Michael Wittig; Jochen Hampe; David N Cooper
Journal: Hum Mutat Date: 2007-02 Impact factor: 4.878

1. Analysis of the genetic variation of vascular endothelial growth factor gene in three Chinese indigenous cattle breeds.

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1 in total