OBJECTIVE: To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery. METHODS: A total of 427 coronary artery bypass graft (CABG) patients were genotyped for two polymorphisms and assessed for depressive symptoms at three time points, in accordance with the Center for Epidemiological Studies-Depression (CES-D): preoperative baseline; 6 months postoperative; and 1 year postoperative. Logistic regression was used to assess the association between depressive symptoms (CES-D = >16), genotype differences, and cardiac events. Because MAOA-uVNTR is sex-linked, males and females were analyzed separately for this polymorphism; sexes were combined for the 5HTTLPR analysis. RESULTS: Depressed patients were more likely than nondepressed patients to have a new cardiac event within 2 years of surgery (p < .0001); depressed patients who carry the long (L) allele of the 5HTTLPR polymorphism were more likely than the short/short (S/S carriers to have an event (p = .0002). Genetic associations with 6-month and 1-year postoperative depressive symptoms do not survive adjustment for baseline depressive symptoms. CONCLUSIONS: A serotonin-related gene polymorphism--5HTTLPR--was associated with adverse cardiac events post CABG, in combination with depressive symptoms. Because depressed patients with the L allele of the 5HTTLPR polymorphism were more likely to have an event compared with the S/S carriers, combining genetic and psychiatric profiling may prove useful in identifying patients at the highest risk for adverse outcomes post CABG.
OBJECTIVE: To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery. METHODS: A total of 427 coronary artery bypass graft (CABG) patients were genotyped for two polymorphisms and assessed for depressive symptoms at three time points, in accordance with the Center for Epidemiological Studies-Depression (CES-D): preoperative baseline; 6 months postoperative; and 1 year postoperative. Logistic regression was used to assess the association between depressive symptoms (CES-D = >16), genotype differences, and cardiac events. Because MAOA-uVNTR is sex-linked, males and females were analyzed separately for this polymorphism; sexes were combined for the 5HTTLPR analysis. RESULTS:Depressedpatients were more likely than nondepressed patients to have a new cardiac event within 2 years of surgery (p < .0001); depressedpatients who carry the long (L) allele of the 5HTTLPR polymorphism were more likely than the short/short (S/S carriers to have an event (p = .0002). Genetic associations with 6-month and 1-year postoperative depressive symptoms do not survive adjustment for baseline depressive symptoms. CONCLUSIONS: A serotonin-related gene polymorphism--5HTTLPR--was associated with adverse cardiac events post CABG, in combination with depressive symptoms. Because depressedpatients with the L allele of the 5HTTLPR polymorphism were more likely to have an event compared with the S/S carriers, combining genetic and psychiatric profiling may prove useful in identifying patients at the highest risk for adverse outcomes post CABG.
Authors: Redford B Williams; Douglas A Marchuk; Kishore M Gadde; John C Barefoot; Katherine Grichnik; Michael J Helms; Cynthia M Kuhn; James G Lewis; Saul M Schanberg; Mark Stafford-Smith; Edward C Suarez; Greg L Clary; Ingrid K Svenson; Ilene C Siegler Journal: Neuropsychopharmacology Date: 2002-08-29 Impact factor: 7.853
Authors: E M Whyte; B G Pollock; W R Wagner; B H Mulsant; R E Ferrell; S Mazumdar; C F Reynolds Journal: Am J Psychiatry Date: 2001-12 Impact factor: 18.112
Authors: James A Blumenthal; Heather S Lett; Michael A Babyak; William White; Peter K Smith; Daniel B Mark; Robert Jones; Joseph P Mathew; Mark F Newman Journal: Lancet Date: 2003-08-23 Impact factor: 79.321
Authors: Heather S Lett; James A Blumenthal; Michael A Babyak; Andrew Sherwood; Timothy Strauman; Clive Robins; Mark F Newman Journal: Psychosom Med Date: 2004 May-Jun Impact factor: 4.312
Authors: Redford B Williams; George D Bishop; Brett C Haberstick; Andrew Smolen; Beverly H Brummett; Ilene C Siegler; Michael A Babyak; Xiaodong Zhang; E Shyong Tai; Jeannette Jen-Mai Lee; Maudrene Tan; Yik Ying Teo; Shiwei Cai; Edmund Chan; Carolyn Tucker Halpern; Eric A Whitsel; Shawn Bauldry; Kathleen Mullan Harris Journal: Am Heart J Date: 2016-12-29 Impact factor: 4.749
Authors: Srijan Sen; Henry R Kranzler; John H Krystal; Heather Speller; Grace Chan; Joel Gelernter; Constance Guille Journal: Arch Gen Psychiatry Date: 2010-04-05
Authors: Courtney J Balentine; Jesus Hermosillo-Rodriguez; Celia N Robinson; David H Berger; Aanand D Naik Journal: J Gastrointest Surg Date: 2011-07-23 Impact factor: 3.452
Authors: Thalida E Arpawong; Jinkook Lee; Drystan F Phillips; Eileen M Crimmins; Morgan E Levine; Carol A Prescott Journal: Behav Genet Date: 2015-09-02 Impact factor: 2.805