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Literature DB >> 19005021

Use of a surrogate chimeric virus to detect West Nile virus-neutralizing antibodies in avian and equine sera.

Nicholas Komar¹, Stanley Langevin, Thomas P Monath.

Abstract

A chimeric yellow fever virus/West Nile virus (WNV) was compared to WNV alone as a biosafety level 2 reagent in the plaque reduction neutralization test for determining WNV infection histories. Concordance was 96.3% among 188 avian and equine serum samples. Neutralizing antibody titers were frequently more than twofold lower with the chimera.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Viral

Year: 2008 PMID： 19005021 PMCID： PMC2620674 DOI： 10.1128/CVI.00220-08

Source DB: PubMed Journal: Clin Vaccine Immunol ISSN： 1556-679X

9 in total

1. Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool.

Authors: Konstantin V Pugachev; Farshad Guirakhoo; Fred Mitchell; Simeon W Ocran; Megan Parsons; Barbara W Johnson; Olga L Kosoy; Robert S Lanciotti; John T Roehrig; Dennis W Trent; Thomas P Monath
Journal: Am J Trop Med Hyg Date: 2004-11 Impact factor: 2.345

2. Induction of epitope-specific neutralizing antibodies against West Nile virus.

Authors: Theodore Oliphant; Grant E Nybakken; S Kyle Austin; Qing Xu; Jonathan Bramson; Mark Loeb; Mark Throsby; Daved H Fremont; Theodore C Pierson; Michael S Diamond
Journal: J Virol Date: 2007-08-22 Impact factor: 5.103

3. Serologic evidence for West Nile virus infection in birds in the New York City vicinity during an outbreak in 1999.

Authors: N Komar; N A Panella; J E Burns; S W Dusza; T M Mascarenhas; T O Talbot
Journal: Emerg Infect Dis Date: 2001 Jul-Aug Impact factor: 6.883

4. Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model.

Authors: M T Long; E P J Gibbs; M W Mellencamp; R A Bowen; K K Seino; S Zhang; S E Beachboard; P P Humphrey
Journal: Equine Vet J Date: 2007-11 Impact factor: 2.888

1 in total

1. Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.

Authors: Payal D Maharaj; Michael Anishchenko; Stanley A Langevin; Ying Fang; William K Reisen; Aaron C Brault
Journal: J Gen Virol Date: 2011-09-21 Impact factor: 3.891

1 in total

Use of a surrogate chimeric virus to detect West Nile virus-neutralizing antibodies in avian and equine sera.

1. Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool.

2. Induction of epitope-specific neutralizing antibodies against West Nile virus.

3. Serologic evidence for West Nile virus infection in birds in the New York City vicinity during an outbreak in 1999.

4. Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model.

5. Serologic evidence for West Nile virus infection in birds in Staten Island, New York, after an outbreak in 2000.

6. The neutralizing antibody response against West Nile virus in naturally infected horses.

7. West Nile virus outbreak among horses in New York State, 1999 and 2000.

Review 8. Yellow fever vector live-virus vaccines: West Nile virus vaccine development.

9. Experimental infection of North American birds with the New York 1999 strain of West Nile virus.

1. Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.