Literature DB >> 1900474

Protein kinase C subspecies in adult rat hippocampal synaptosomes. Activation by diacylglycerol and arachidonic acid.

M S Shearman1, T Shinomura, T Oda, Y Nishizuka.   

Abstract

Synaptosomes isolated from the adult rat hippocampus contain the alpha- and beta-subspecies of protein kinase C (PKC), but not the gamma-subspecies which is abundantly expressed in the pyramidal cells in this brain region. Although the gamma-subspecies is known to respond significantly to free arachidonic acid, it is found that both the alpha- and beta-subspecies are also activated dramatically by arachidonic acid in synergistic action with diacylglycerol. Oleic, linoleic, and linolenic acids are all active. It is possible that unsaturated fatty acids may take part in the activation of alpha- and beta-subspecies of PKC which are present in the presynaptic nerve endings terminating at the hippocampal pyramidal cells.

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Year:  1991        PMID： 1900474     DOI： 10.1016/0014-5793(91)80163-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

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5.  Potentiation of transmitter release by protein kinase C in goldfish retinal bipolar cells.

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6.  Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.

Authors:  G N Rao; B Lasségue; K K Griendling; R W Alexander; B C Berk
Journal:  Nucleic Acids Res       Date:  1993-03-11       Impact factor: 16.971

7.  Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

Authors:  T Shinomura; Y Asaoka; M Oka; K Yoshida; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

8.  Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.

Authors:  S G Chen; K Murakami
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

9.  Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets.

Authors:  R J Konrad; Y C Jolly; C Major; B A Wolf
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857
  9 in total

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