Literature DB >> 1900473

Modulation of a Shaker potassium A-channel by protein kinase C activation.

O Moran1, N Dascal, I Lotan.   

Abstract

Brain fast transient K+ channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effect is a small change in the voltage-dependence of activation and inactivation of the channel.

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Year:  1991        PMID： 1900473     DOI： 10.1016/0014-5793(91)80162-v

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Kv4.2 is a locus for PKC and ERK/MAPK cross-talk.

Authors:  Laura A Schrader; Yajun Ren; Feng Cheng; Dui Bui; J David Sweatt; Anne E Anderson
Journal:  Biochem J       Date:  2009-02-01       Impact factor: 3.857

2.  Layer-specific properties of the transient K current (IA) in piriform cortex.

Authors:  M I Banks; L B Haberly; M B Jackson
Journal:  J Neurosci       Date:  1996-06-15       Impact factor: 6.167

3.  Alternative splicing in the pore-forming region of shaker potassium channels.

Authors:  M Kim; D J Baro; C C Lanning; M Doshi; J Farnham; H S Moskowitz; J H Peck; B M Olivera; R M Harris-Warrick
Journal:  J Neurosci       Date:  1997-11-01       Impact factor: 6.167

4.  Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones.

Authors:  N A Lozovaya; C A Vulfius; V I Ilyin; I V Krasts
Journal:  J Physiol       Date:  1993-05       Impact factor: 5.182

5.  Modulation by protein kinase A of a cloned rat brain potassium channel expressed in Xenopus oocytes.

Authors:  G G Wilson; C A O'Neill; A Sivaprasadarao; J B Findlay; D Wray
Journal:  Pflugers Arch       Date:  1994-09       Impact factor: 3.657

6.  Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate.

Authors:  M Covarrubias; A Wei; L Salkoff; T B Vyas
Journal:  Neuron       Date:  1994-12       Impact factor: 17.173

7.  Modulation of type A K+ current in Drosophila larval muscle by internal Ca2+; effects of the overexpression of frequenin.

Authors:  C Poulain; A Ferrús; A Mallart
Journal:  Pflugers Arch       Date:  1994-05       Impact factor: 3.657

8.  Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes.

Authors:  E Bourinet; F Fournier; P Lory; P Charnet; J Nargeot
Journal:  Pflugers Arch       Date:  1992-06       Impact factor: 3.657

9.  Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes.

Authors:  A E Busch; M P Kavanaugh; M D Varnum; J P Adelman; R A North
Journal:  J Physiol       Date:  1992-05       Impact factor: 5.182

10.  Classical conditioning and protein kinase C activation regulate the same single potassium channel in Hermissenda crassicornis photoreceptors.

Authors:  R Etcheberrigaray; L D Matzel; I I Lederhendler; D L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205
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