Literature DB >> 19003219

Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures.

Evrim Ipek1, Berrin Ayaz Tüylü, Hülya Zeytinoğlu.   

Abstract

Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. The genotoxicity test was performed with carvacrol in two donors. On the other hand, inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.

Entities:  

Year:  2003        PMID： 19003219      PMCID： PMC3449596          DOI： 10.1023/b:cyto.0000039896.26707.40

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  10 in total

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6.  Influence of carvacrol on growth and toxin production by Bacillus cereus.

Authors:  A Ultee; E J Smid
Journal:  Int J Food Microbiol       Date:  2001-03-20       Impact factor: 5.277

7.  Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo.

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Journal:  J Nutr       Date:  1997-05       Impact factor: 4.798

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Journal:  Food Chem Toxicol       Date:  1994-01       Impact factor: 6.023

9.  Bactericidal activity of carvacrol towards the food-borne pathogen Bacillus cereus.

Authors:  A Ultee; L G Gorris; E J Smid
Journal:  J Appl Microbiol       Date:  1998-08       Impact factor: 3.772

10.  Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene.

Authors:  H Zeytinoglu; Z Incesu; K H C Baser
Journal:  Phytomedicine       Date:  2003-05       Impact factor: 5.340
  10 in total
  6 in total

1.  Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2.

Authors:  Qing-Hua Yin; Feng-Xiang Yan; Xu-Yu Zu; You-Hua Wu; Xiao-Ping Wu; Ming-Chu Liao; Shu-Wen Deng; Lei-Lan Yin; Ying-Zhi Zhuang
Journal:  Cytotechnology       Date:  2011-09-22       Impact factor: 2.058

2.  Carvacrol attenuates mechanical hypernociception and inflammatory response.

Authors:  Adriana G Guimarães; Maria A Xavier; Marília T de Santana; Enilton A Camargo; Cliomar A Santos; Fabíola A Brito; Emiliano O Barreto; Sócrates C H Cavalcanti; Angelo R Antoniolli; Rita C M Oliveira; Lucindo J Quintans-Júnior
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-12-03       Impact factor: 3.000

3.  The effect of carvacrol on healthy neurons and N2a cancer cells: some biochemical, anticancerogenicity and genotoxicity studies.

Authors:  Elanur Aydın; Hasan Türkez; M Sait Keleş
Journal:  Cytotechnology       Date:  2013-04-04       Impact factor: 2.058

4.  Effects of Thymus kotschyanus var. glabrescens Boiss. extract on mitomycin-C induced chromosomal aberrations and sister chromatid exchanges in human lymphocytes.

Authors:  Mustafa Celik; Fatma Unal; Deniz Yüzbaşıoğlu; Serkan Yılmaz; Hüseyin Aksoy; Sengül Karaman
Journal:  Cytotechnology       Date:  2006-09-21       Impact factor: 2.058

5.  Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism.

Authors:  Neeraj Kumar; Anita Yadav; Sachin Gulati; Neeraj Aggarwal; Ranjan Gupta
Journal:  J Toxicol       Date:  2014-09-25

6.  Carvacrol attenuates serum levels of total protein, phospholipase A2 and histamine in asthmatic guinea pig.

Authors:  Mohammad Hossein Boskabady; Sedigheh Jalali; Negin Yahyazadeh; Mostafa Boskabady
Journal:  Avicenna J Phytomed       Date:  2016 Nov-Dec
  6 in total

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