Literature DB >> 19002570

The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis.

Robert A Jones1, Roger A Moorehead.   

Abstract

Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been available for about the same period of time, it is surprising that transgenic mice overexpressing the IGF-IR in the mammary gland have only recently been characterized. This review will describe the effects of IGF-IR overexpression on mammary ductal morphogenesis and mammary tumorigenesis in the two available transgenic models.

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Year:  2008        PMID： 19002570     DOI： 10.1007/s10911-008-9097-1

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  52 in total

1.  Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.

Authors:  Joan M Carboni; Adrian V Lee; Darryl L Hadsell; Bruce R Rowley; Francis Y Lee; David K Bol; Amy E Camuso; Marco Gottardis; Ann F Greer; Ching Ping Ho; Warren Hurlburt; Aixin Li; Mark Saulnier; Upender Velaparthi; Cindy Wang; Mei-Li Wen; Richard A Westhouse; Mark Wittman; Kurt Zimmermann; Brent A Rupnow; Tai W Wong
Journal:  Cancer Res       Date:  2005-05-01       Impact factor: 12.701

2.  Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.

Authors:  J L Resnik; D B Reichart; K Huey; N J Webster; B L Seely
Journal:  Cancer Res       Date:  1998-03-15       Impact factor: 12.701

3.  Expression of insulin-like growth factor-I receptor, estrogen receptor alpha, Bcl-2 and Bax proteins in human breast cancer.

Authors:  Mariusz Koda; Wojciech Przystupa; Katarzyna Jarzabek; Andrzej Wincewicz; Luiza Kanczuga-Koda; Jakub Tomaszewski; Mariola Sulkowska; Slawomir Wolczynski; Stanislaw Sulkowski
Journal:  Oncol Rep       Date:  2005-07       Impact factor: 3.906

4.  Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations.

Authors:  Sharon Maor; Ady Yosepovich; Moshe Z Papa; Ronit I Yarden; Doris Mayer; Eitan Friedman; Haim Werner
Journal:  Cancer Lett       Date:  2007-09-04       Impact factor: 8.679

5.  Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds.

Authors:  S G Bonnette; D L Hadsell
Journal:  Endocrinology       Date:  2001-11       Impact factor: 4.736

6.  Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.

Authors:  Darryl L Hadsell; Daniel T Torres; Nicole A Lawrence; Jessy George; Albert F Parlow; Adrian V Lee; Marta L Fiorotto
Journal:  Biol Reprod       Date:  2005-08-03       Impact factor: 4.285

7.  Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice.

Authors:  T C Wang; R D Cardiff; L Zukerberg; E Lees; A Arnold; E V Schmidt
Journal:  Nature       Date:  1994-06-23       Impact factor: 49.962

Review 8.  Transitions between epithelial and mesenchymal states in development and disease.

Authors:  Buzz Baum; Jeffrey Settleman; Margaret P Quinlan
Journal:  Semin Cell Dev Biol       Date:  2008-02-09       Impact factor: 7.727

9.  Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by the type I insulin-like growth factor receptor.

Authors:  Robert A Jones; Craig I Campbell; James J Petrik; Roger A Moorehead
Journal:  Mol Cancer Res       Date:  2008-05       Impact factor: 5.852

10.  Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups.

Authors:  D G Burrin; M L Fiorotto; D L Hadsell
Journal:  J Nutr       Date:  1999-01       Impact factor: 4.798
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  12 in total

1.  Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.

Authors:  Desma M Grice; Irina Vetter; Helen M Faddy; Paraic A Kenny; Sarah J Roberts-Thomson; Gregory R Monteith
Journal:  J Biol Chem       Date:  2010-09-13       Impact factor: 5.157

2.  Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats.

Authors:  Tiffany A Polanco; Catina Crismale-Gann; Kenneth R Reuhl; Dipak K Sarkar; Wendie S Cohick
Journal:  Alcohol Clin Exp Res       Date:  2010-11       Impact factor: 3.455

3.  Clinical pathological characteristics and prognostic analysis of diabetic women with luminal subtype breast cancer.

Authors:  Yuanting Xiao; Sheng Zhang; Guofang Hou; Xiaobei Zhang; Xiaomeng Hao; Jin Zhang
Journal:  Tumour Biol       Date:  2013-10-05

4.  Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.

Authors:  Kristopher C Carver; Timothy M Piazza; Linda A Schuler
Journal:  J Biol Chem       Date:  2010-01-15       Impact factor: 5.157

5.  ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis.

Authors:  Craig I Campbell; James J Petrik; Roger A Moorehead
Journal:  Mol Cancer       Date:  2010-09-08       Impact factor: 27.401

6.  Insulin-like growth factor-1 receptor (IGF-1R) expression on circulating tumor cells (CTCs) and metastatic breast cancer outcome: results from the TransMYME trial.

Authors:  Alessandra Gennari; Flavia Foca; Rita Zamarchi; Andrea Rocca; Dino Amadori; Andrea De Censi; Alessandra Bologna; Luigi Cavanna; Lorenzo Gianni; Laura Scaltriti; Elisabetta Rossi; Antonella Facchinetti; Veronica Martini; Paolo Bruzzi; Oriana Nanni
Journal:  Breast Cancer Res Treat       Date:  2020-03-21       Impact factor: 4.872

7.  IGF-I during primiparous pregnancy and maternal risk of breast cancer.

Authors:  Tianhui Chen; Annekatrin Lukanova; Kjell Grankvist; Anne Zeleniuch-Jacquotte; Marianne Wulff; Robert Johansson; Helena Schock; Per Lenner; Goran Hallmans; Goran Wadell; Paolo Toniolo; Eva Lundin
Journal:  Breast Cancer Res Treat       Date:  2009-09-02       Impact factor: 4.872

8.  Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

Authors:  Xingxing Liu; Vincent Giguère
Journal:  Nucl Recept Signal       Date:  2014-11-04

9.  Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer.

Authors:  Kristina E Aaltonen; Ann H Rosendahl; Hans Olsson; Per Malmström; Linda Hartman; Mårten Fernö
Journal:  BMC Cancer       Date:  2014-11-03       Impact factor: 4.430

Review 10.  Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer.

Authors:  Lauren M Rota; Teresa L Wood
Journal:  Front Endocrinol (Lausanne)       Date:  2015-06-09       Impact factor: 6.055
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