| Literature DB >> 19000729 |
Hayet Douik1, Arij Ben Chaaben, Neila Attia Romdhane, Habiba Ben Romdhane, Tesnim Mamoghli, Catherine Fortier, Wahid Boukouaci, Latifa Harzallah, Abderraouf Ghanem, Said Gritli, Mohamed Makni, Dominique Charron, Rajagopal Krishnamoorthy, Fethi Guemira, Ryad Tamouza.
Abstract
Major histocompatibility complex (MHC) class I chain-related A (MICA) molecules mediate natural killer (NK) cell activation and T lymphocyte co-stimulation. A polymorphic methionine (met) to valine (val) variation at amino acid position 129 of the alpha2 heavy chain domain is in linkage disequilibrium with other allelic changes and seems to categorize MICA alleles into strong and weak binder of NKG2D receptor and thereby to influence effector cell function. We investigated here whether MICA-129 dimorphism is associated with susceptibility to/or resistance against developing nasopharyngeal cancer (NPC). DNA from 130 NPC patients and 180 healthy individuals from Tunisia were genotyped for MICA-129 variation. We found a higher frequency of MICA-129 val/val genotype in patients than in controls (corrected p value = 0.02) that could suggest a tumor escape mechanism because of failure to activate NK cells by MICA-129 val allele or absence of NK cell activation because of absence of MICA-129 met allele in individuals otherwise predisposed to viral/environmental factors.Entities:
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Year: 2008 PMID： 19000729 DOI： 10.1016/j.humimm.2008.10.008
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850