OBJECTIVES: The relationship between Fe status and HIV infection is complex and poorly understood. While anaemia is a major complication of HIV infection, higher Fe stores may be associated with disease progression. There is limited and conflicting data available from Africa. DESIGN: Cross-sectional and prospective cohort study. SETTING, SUBJECTS AND METHODS: We examined the association between postpartum Fe status (Hb, serum ferritin (SF) and transferrin receptor (TfR)) and viral load (VL) and HIV-related mortality in 643 HIV-positive Zimbabwean women over a period of 12 months. RESULTS: In non-anaemic women a log10 increase in SF was associated with a 2.3-fold increase in VL (P = 0.019); this association was absent in anaemic women. In prospective analyses, a log10 increase in SF was associated with a 4-fold increase in mortality by 12 months (P = 0.002). Hb was negatively associated with VL (P = 0.001) and mortality (P = 0.047). The adverse associations between SF and both VL and mortality were found at SF concentrations > 45 microg/l (P < 0.05). Controlling for alpha1 acid glycoprotein, a marker of inflammation, attenuated the association between both SF and VL and mortality, but these remained significant. CONCLUSIONS: These results are consistent with the hypothesis that high Fe stores have adverse consequences in HIV infection. If adverse consequences are real, our data suggest that they occur at SF concentrations exceeding those consistent with adequate Fe nutriture.
OBJECTIVES: The relationship between Fe status and HIV infection is complex and poorly understood. While anaemia is a major complication of HIV infection, higher Fe stores may be associated with disease progression. There is limited and conflicting data available from Africa. DESIGN: Cross-sectional and prospective cohort study. SETTING, SUBJECTS AND METHODS: We examined the association between postpartum Fe status (Hb, serum ferritin (SF) and transferrin receptor (TfR)) and viral load (VL) and HIV-related mortality in 643 HIV-positive Zimbabwean women over a period of 12 months. RESULTS: In non-anaemic women a log10 increase in SF was associated with a 2.3-fold increase in VL (P = 0.019); this association was absent in anaemic women. In prospective analyses, a log10 increase in SF was associated with a 4-fold increase in mortality by 12 months (P = 0.002). Hb was negatively associated with VL (P = 0.001) and mortality (P = 0.047). The adverse associations between SF and both VL and mortality were found at SF concentrations > 45 microg/l (P < 0.05). Controlling for alpha1 acid glycoprotein, a marker of inflammation, attenuated the association between both SF and VL and mortality, but these remained significant. CONCLUSIONS: These results are consistent with the hypothesis that high Fe stores have adverse consequences in HIV infection. If adverse consequences are real, our data suggest that they occur at SF concentrations exceeding those consistent with adequate Fe nutriture.
Authors: Donald N Forthal; Tran B Phan; Anatoly V Slepenkin; Gary Landucci; Hencelyn Chu; Mikael Elofsson; Ellena Peterson Journal: Int J Antimicrob Agents Date: 2012-07-20 Impact factor: 5.283
Authors: Batool A Haider; Donna Spiegelman; Ellen Hertzmark; David Sando; Christopher Duggan; Abel Makubi; Christopher Sudfeld; Eric Aris; Guerino E Chalamilla; Wafaie W Fawzi Journal: Am J Trop Med Hyg Date: 2019-06 Impact factor: 2.345
Authors: Andrew E Armitage; Andrea R Stacey; Eleni Giannoulatou; Elizabeth Marshall; Pamela Sturges; Kamaljit Chatha; Nicola M G Smith; XiaoJie Huang; XiaoNing Xu; Sant-Rayn Pasricha; Ning Li; Hao Wu; Craig Webster; Andrew M Prentice; Pierre Pellegrino; Ian Williams; Phillip J Norris; Hal Drakesmith; Persephone Borrow Journal: Proc Natl Acad Sci U S A Date: 2014-08-04 Impact factor: 11.205