OBJECTIVE: To study the cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on human hepatoma cell line HepG2 cultured in vitro. METHODS: Three groups were divided: compounds group, 5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilomyces sp. Tree 1-7. RESULTS: Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2, the IC50 separately were 2.0, 62.1 and 7.0 microg/ml. CONCLUSION: Secalonic acid A and alternin have strong cytotoxicity on HepG2 cultured in vitro.
OBJECTIVE: To study the cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on humanhepatoma cell line HepG2 cultured in vitro. METHODS: Three groups were divided: compounds group, 5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilomyces sp. Tree 1-7. RESULTS:Secalonic acid A, tenellic acid A and alternin inhibited the growth of humanhepatoma cell line HepG2, the IC50 separately were 2.0, 62.1 and 7.0 microg/ml. CONCLUSION:Secalonic acid A and alternin have strong cytotoxicity on HepG2 cultured in vitro.