| Literature DB >> 18998050 |
Takuya Fukushima1, Kensuke Horio2, Emi Matsuo2, Daisuke Imanishi2, Reishi Yamasaki2, Hideki Tsushima2, Yoshitaka Imaizumi2, Koichi Ohshima3, Tomoko Hata2, Shinichiro Yoshida4, Yasushi Miyazaki2, Masao Tomonaga2.
Abstract
A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.Entities:
Mesh:
Year: 2008 PMID: 18998050 DOI: 10.1007/s12185-008-0190-4
Source DB: PubMed Journal: Int J Hematol ISSN: 0925-5710 Impact factor: 2.490