Literature DB >> 18997396

Synthesis and anti-angiogenic activity of cortistatin analogs.

Yuuki Sato1, Hiroshi Kamiyama, Takeo Usui, Tamio Saito, Hiroyuki Osada, Shigefumi Kuwahara, Hiromasa Kiyota.   

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

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Year:  2008        PMID： 18997396     DOI： 10.1271/bbb.80562

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

2.  Formal total synthesis of (±)-cortistatin A.

Authors:  Eric M Simmons; Alison R Hardin-Narayan; Xuelei Guo; Richmond Sarpong
Journal:  Tetrahedron       Date:  2010-06-26       Impact factor: 2.457

3.  Creation of readily accessible and orally active analogue of cortistatin a.

Authors:  Naoyuki Kotoku; Yuji Sumii; Takeshi Hayashi; Satoru Tamura; Takashi Kawachi; Sho Shiomura; Masayoshi Arai; Motomasa Kobayashi
Journal:  ACS Med Chem Lett       Date:  2012-07-10       Impact factor: 4.345

4.  Scalable synthesis of cortistatin A and related structures.

Authors:  Jun Shi; Georg Manolikakes; Chien-Hung Yeh; Carlos A Guerrero; Ryan A Shenvi; Hiroki Shigehisa; Phil S Baran
Journal:  J Am Chem Soc       Date:  2011-05-03       Impact factor: 15.419

5.  Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues.

Authors:  Jun Shi; Hiroki Shigehisa; Carlos A Guerrero; Ryan A Shenvi; Chuang-Chuang Li; Phil S Baran
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 6.  Angiosuppressive properties of marine-derived compounds-a mini review.

Authors:  Patrick Y K Yue; H M Leung; Adela J Li; Tracy N C Chan; T S Lum; Y L Chung; Y H Sung; M H Wong; Kelvin S Y Leung; Eddy Y Zeng
Journal:  Environ Sci Pollut Res Int       Date:  2015-10-31       Impact factor: 4.223

7.  Synthetic studies of biologically active natural products contributing to pesticide development.

Authors:  Hiromasa Kiyota
Journal:  J Pestic Sci       Date:  2020-08-20       Impact factor: 2.529
  7 in total

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