Literature DB >> 18997393

Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A.

Hirosato Takikawa1, Naoki Kamatani, Kohei Nakanishi, Takuya Tashiro, Mitsuru Sasaki, Hiromi Yoshida, Yoshiyuki Mizushina.   

Abstract

Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

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Year:  2008        PMID： 18997393     DOI： 10.1271/bbb.80629

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  2 in total

Review 1.  Targeting DNA polymerase ß for therapeutic intervention.

Authors:  Eva M Goellner; David Svilar; Karen H Almeida; Robert W Sobol
Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

2.  The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta.

Authors:  Yoshiyuki Mizushina; Daisuke Manita; Toshifumi Takeuchi; Fumio Sugawara; Yuko Kumamoto-Yonezawa; Yuki Matsui; Masaharu Takemura; Mitsuru Sasaki; Hiromi Yoshida; Hirosato Takikawa
Journal:  Molecules       Date:  2008-12-29       Impact factor: 4.411
  2 in total

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