BACKGROUND: Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis. OBJECTIVE: We examined the relation of fish and seafood n-3 fatty acid intakes with prostate cancer incidence and mortality. DESIGN: We conducted a prospective cohort study among 20,167 men participating in the Physician's Health Study who were free of cancer in 1983. RESULTS: During 382 144 person-years of follow-up, 2161 men were diagnosed with prostate cancer and 230 died of prostate cancer. Fish intake was unrelated to prostate cancer incidence. Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases. CONCLUSION: These results suggest that fish intake is unrelated to prostate cancer incidence but may improve prostate cancer survival.
BACKGROUND: Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis. OBJECTIVE: We examined the relation of fish and seafood n-3 fatty acid intakes with prostate cancer incidence and mortality. DESIGN: We conducted a prospective cohort study among 20,167 men participating in the Physician's Health Study who were free of cancer in 1983. RESULTS: During 382 144 person-years of follow-up, 2161 men were diagnosed with prostate cancer and 230 died of prostate cancer. Fish intake was unrelated to prostate cancer incidence. Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases. CONCLUSION: These results suggest that fish intake is unrelated to prostate cancer incidence but may improve prostate cancer survival.
Authors: June M Chan; Crystal N Holick; Michael F Leitzmann; Eric B Rimm; Walter C Willett; Meir J Stampfer; Edward L Giovannucci Journal: Cancer Causes Control Date: 2006-03 Impact factor: 2.506
Authors: Kana Wu; Donna Spiegelman; Tao Hou; Demetrius Albanes; Naomi E Allen; Sonja I Berndt; Piet A van den Brandt; Graham G Giles; Edward Giovannucci; R Alexandra Goldbohm; Gary G Goodman; Phyllis J Goodman; Niclas Håkansson; Manami Inoue; Timothy J Key; Laurence N Kolonel; Satu Männistö; Marjorie L McCullough; Marian L Neuhouser; Yikyung Park; Elizabeth A Platz; Jeannette M Schenk; Rashmi Sinha; Meir J Stampfer; Victoria L Stevens; Shoichiro Tsugane; Kala Visvanathan; Lynne R Wilkens; Alicja Wolk; Regina G Ziegler; Stephanie A Smith-Warner Journal: Int J Cancer Date: 2016-05-15 Impact factor: 7.396
Authors: Meng Yang; Azalea Ayuningtyas; Stacey A Kenfield; Howard D Sesso; Hannia Campos; Jing Ma; Meir J Stampfer; Jorge E Chavarro Journal: Cancer Causes Control Date: 2016-08-03 Impact factor: 2.506
Authors: Olakunle O Kassim; Robert L Copeland; Hilaire M Kenguele; Sergei Nekhai; Kwashie A Ako-Nai; Yasmine M Kanaan Journal: Anticancer Res Date: 2015-03 Impact factor: 2.480
Authors: Stacey A Kenfield; Julie L Batista; Jaquelyn L Jahn; Mary Kathryn Downer; Erin L Van Blarigan; Howard D Sesso; Edward L Giovannucci; Meir J Stampfer; June M Chan Journal: J Natl Cancer Inst Date: 2015-11-17 Impact factor: 13.506
Authors: Stacey A Kenfield; Natalie DuPre; Erin L Richman; Meir J Stampfer; June M Chan; Edward L Giovannucci Journal: Eur Urol Date: 2013-08-13 Impact factor: 20.096