Literature DB >> 18996593

Immunophenotyping and immunoglobulin heavy chain gene rearrangement analysis in cerebrospinal fluid of pediatric patients with acute lymphoblastic leukemia.

Douaa Sayed1, Hosny Badrawy, Amany M Ali, Sanaa Shaker.   

Abstract

The study aimed to assess the diagnostic accuracy of Flow cytometry (FCM) immunophenotyping and IgH gene rearrangements (IGHRs) by real-time PCR in comparison with classic cytology for diagnosing CNS infiltration in pediatric ALL. We concluded that the diagnostic value of FCM and IGHR are two to three times more than that of cytology. Therefore, immunophenotyping by FCM is recommended for routine diagnosis of CSF infiltration. Furthermore, IGHR analysis by real-time PCR appears to be a useful addition in evaluation of CNS infiltration.

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Year:  2008        PMID： 18996593     DOI： 10.1016/j.leukres.2008.09.033

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  5 in total

Review 1.  Diagnosis of acute leukemia in cerebrospinal fluid (CSF-acute leukemia).

Authors:  Erick Crespo-Solis; Xavier López-Karpovitch; Jesús Higuera; Beatriz Vega-Ramos
Journal:  Curr Oncol Rep       Date:  2012-10       Impact factor: 5.075

Review 2.  Flow Cytometric Detection of Malignant Blasts in Cerebrospinal Fluid: A Biomarker of Central Nervous System Involvement in Childhood Acute Lymphoblastic Leukemia.

Authors:  Maria Thastrup; Hanne Vibeke Marquart; Kjeld Schmiegelow
Journal:  Biomolecules       Date:  2022-06-09

Review 3.  Central nervous system involvement in adult acute lymphoblastic leukemia: diagnostic tools, prophylaxis, and therapy.

Authors:  Maria Ilaria Del Principe; Luca Maurillo; Francesco Buccisano; Giuseppe Sconocchia; Mariagiovanna Cefalo; Giovanna De Santis; Ambra Di Veroli; Concetta Ditto; Daniela Nasso; Massimiliano Postorino; Marco Refrigeri; Cristina Attrotto; Giovanni Del Poeta; Francesco Lo-Coco; Sergio Amadori; Adriano Venditti
Journal:  Mediterr J Hematol Infect Dis       Date:  2014-11-01       Impact factor: 2.576

Review 4.  The influence of fixation of biological samples on cell count and marker expression stability in flow cytometric analyses.

Authors:  Łukasz SĘdek; Jan Kulis; Łukasz SŁota; Magdalena Twardoch; Magdalena Pierzyna-ŚwitaŁa; Bartosz Perkowski; Tomasz SzczepaŃski
Journal:  Cent Eur J Immunol       Date:  2020-06-08       Impact factor: 2.085

5.  Clinical significance of occult central nervous system disease in adult acute lymphoblastic leukemia. A multicenter report from the Campus ALL Network.

Authors:  Maria Ilaria Del Principe; Elisa Buzzatti; Alfonso Piciocchi; Fabio Forghieri; Massimiliano Bonifacio; Federica Lessi; Silvia Imbergamo; Enrico Orciuolo; Giovanni Rossi; Nicola Fracchiolla; Silvia Trappolini; Benedetta Neri; Chiara Sarlo; Patrizia Zappasodi; Michelina Dargenio; Mariagiovanna Cefalo; Maria Antonietta Irno-Consalvo; Consuelo Conti; Giovangiacinto Paterno; Gottardo De Angelis; Mariarita Sciumè; Irene Della Starza; Adriano Venditti; Robin Foà; Anna Rita Guarini
Journal:  Haematologica       Date:  2021-01-01       Impact factor: 9.941
  5 in total

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