Literature DB >> 18996428

The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+gamma/deltaTCR-CD45RO+ T-cell population.

Alison E Hogg1, Andrew Worth, Peter Beverley, Christopher J Howard, Bernardo Villarreal-Ramos.   

Abstract

Tuberculosis (TB) remains a worldwide leading cause of death among infectious diseases. Development of safer and more efficacious vaccines requires a basic understanding of the protective mechanisms induced by BCG. Here we show that vaccination of cattle with BCG induces CD8+gamma/deltaTCR-CD45RO+ T-cells that can produce IFN-gamma, up-regulate transcription and expression of perforin, lyse BCG-infected monocyte-derived macrophages (MoMvarphi) and contribute to a reduction in the number of intracellular mycobacteria. We also observed BCG-induced CD8+ responses in vivo. After infection of cattle with Mycobacterium bovis, CD8+gamma/deltaTCR-CD45RO+ cells responded more strongly to M. bovis-infected MoMvarphi than to BCG-infected MoMvarphi. These results indicate that the antigen-specific CD8+ memory response resides in the CD8+gamma/deltaTCR-CD45RO+ cell population.

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Year:  2008        PMID： 18996428     DOI： 10.1016/j.vaccine.2008.10.053

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  12 in total

1.  Recombinant Mycobacterium bovis BCG expressing the chimeric protein of antigen 85B and ESAT-6 enhances the Th1 cell-mediated response.

Authors:  Ying Xu; Wei Liu; Hongbo Shen; Jingran Yan; Di Qu; Honghai Wang
Journal:  Clin Vaccine Immunol       Date:  2009-06-10

2.  Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates.

Authors:  Sayma Rahman; Isabelle Magalhaes; Jubayer Rahman; Raija K Ahmed; Donata R Sizemore; Charles A Scanga; Frank Weichold; Frank Verreck; Ivanela Kondova; Jerry Sadoff; Rigmor Thorstensson; Mats Spångberg; Mattias Svensson; Jan Andersson; Markus Maeurer; Susanna Brighenti
Journal:  Mol Med       Date:  2012-05-09       Impact factor: 6.354

Review 3.  Targeting mucosal immunity in the battle to develop a mastitis vaccine.

Authors:  Mini Bharathan; Isis K Mullarky
Journal:  J Mammary Gland Biol Neoplasia       Date:  2011-10-04       Impact factor: 2.673

4.  Host responses to persistent Mycobacterium avium subspecies paratuberculosis infection in surgically isolated bovine ileal segments.

Authors:  Chandrashekhar Charavaryamath; Patricia Gonzalez-Cano; Patrick Fries; Susantha Gomis; Kimberley Doig; Erin Scruten; Andrew Potter; Scott Napper; Philip J Griebel
Journal:  Clin Vaccine Immunol       Date:  2012-12-05

Review 5.  Six-of-the-best: unique contributions of γδ T cells to immunology.

Authors:  Pierre Vantourout; Adrian Hayday
Journal:  Nat Rev Immunol       Date:  2013-02       Impact factor: 53.106

6.  Characterization of effector and memory T cell subsets in the immune response to bovine tuberculosis in cattle.

Authors:  Mayara F Maggioli; Mitchell V Palmer; Tyler C Thacker; H Martin Vordermeier; W Ray Waters
Journal:  PLoS One       Date:  2015-04-16       Impact factor: 3.240

7.  A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus.

Authors:  Sabine Riffault; Gilles Meyer; Martine Deplanche; Catherine Dubuquoy; Guillaume Durand; Marion Soulestin; Nathalie Castagné; Julie Bernard; Philippe Bernardet; Virginie Dubosclard; Florence Bernex; Agnès Petit-Camurdan; Sébastien Deville; Isabelle Schwartz-Cornil; Jean-François Eléouët
Journal:  Vaccine       Date:  2010-03-20       Impact factor: 3.641

8.  A Mycobacterium bovis BCG-naked DNA prime-boost vaccination strategy induced CD4⁺ and CD8⁺ T-cell response against Mycobacterium tuberculosis immunogens.

Authors:  Miao Lu; Zhi Yang Xia; Lang Bao
Journal:  J Immunol Res       Date:  2014-03-11       Impact factor: 4.818

9.  Variegated Transcription of the WC1 Hybrid PRR/Co-Receptor Genes by Individual γδ T Cells and Correlation With Pathogen Responsiveness.

Authors:  Payal Damani-Yokota; Janice C Telfer; Cynthia L Baldwin
Journal:  Front Immunol       Date:  2018-05-07       Impact factor: 7.561

10.  Immune response to influenza vaccination in the elderly is altered by chronic medication use.

Authors:  Divyansh Agarwal; Kenneth E Schmader; Andrew V Kossenkov; Susan Doyle; Raj Kurupati; Hildegund C J Ertl
Journal:  Immun Ageing       Date:  2018-08-31       Impact factor: 6.400
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