| Literature DB >> 18996222 |
Yuki Ohsaki1, Jinglei Cheng, Michitaka Suzuki, Yuki Shinohara, Akikazu Fujita, Toyoshi Fujimoto.
Abstract
The cytoplasmic lipid droplet (CLD) and very low-density lipoprotein are generated from the lipid ester synthesized in the endoplasmic reticulum. The lipid ester deposited between the two membrane leaflets is supposed to bulge toward the cytoplasm to make a nascent CLD, but its size must be below the resolution limit of conventional techniques and the detectable CLD should only form after acquisition of additional lipid esters. The CLD is different from vesicular organelles in that the internal content is highly hydrophobic and the shape is invariably spherical. Due to its unique characteristics, quantitative discordance between the surface and the volume may occur in the growth and/or involution processes of the CLD. The possibility that these processes may give rise to the structural and functional diversities of the CLD is discussed.Entities:
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Year: 2008 PMID： 18996222 DOI： 10.1016/j.bbalip.2008.10.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002