| Literature DB >> 18996018 |
Luqing Shang1, Qiang Wang, Hao Fang, Jiajia Mu, Xuejian Wang, Yumei Yuan, Binghe Wang, Wenfang Xu.
Abstract
Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC(50) value 15.5+/-1.2microM.Entities:
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Year: 2008 PMID： 18996018 DOI： 10.1016/j.bmc.2008.10.025
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641