Literature DB >> 18996008

Triterpene based compounds with potent anti-maturation activity against HIV-1.

David Gerrish1, In Chul Kim, Dange V Kumar, Harry Austin, Jennifer E Garrus, Vijay Baichwal, Michael Saunders, Rena S McKinnon, Mark B Anderson, Robert Carlson, Esther Arranz-Plaza, Kraig M Yager.   

Abstract

Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats.

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Year:  2008        PMID： 18996008     DOI： 10.1016/j.bmcl.2008.10.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking.

Authors:  Ping Lan; Wan-Na Chen; Zhi-Jian Huang; Ping-Hua Sun; Wei-Min Chen
Journal:  J Mol Model       Date:  2010-10-27       Impact factor: 1.810

Review 2.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

3.  New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.

Authors:  Wade S Blair; Joan Cao; Juin Fok-Seang; Paul Griffin; Jason Isaacson; R Lynn Jackson; Edward Murray; Amy K Patick; Qinghai Peng; Manos Perros; Chris Pickford; Hua Wu; Scott L Butler
Journal:  Antimicrob Agents Chemother       Date:  2009-10-05       Impact factor: 5.191

4.  Design, synthesis and biological evaluation of novel betulinic acid derivatives.

Authors:  Shengjie Yang; Na Liang; Hu Li; Wei Xue; Deyu Hu; Linhong Jin; Qi Zhao; Song Yang
Journal:  Chem Cent J       Date:  2012-11-23       Impact factor: 4.215
  4 in total

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