Literature DB >> 1899407

Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats.

A A Like1, D L Guberski, L Butler.   

Abstract

Elimination of environmental viruses by cesarean derivation of the University of Massachusetts colony of BB/Wor rats increased the frequency and accelerated the tempo of spontaneous diabetes among diabetes-prone (DP) rats. In contrast, the viral-antibody-free (VAF) environment did not alter the resistance of pre-VAF diabetes-resistant (DR) rats to spontaneous and RT6+ T-lymphocyte-depletion-induced diabetes. Pre-VAF and VAF rats have essentially the same lymphocyte subsets, and VAF-DP rats are susceptible to the adoptive transfer of diabetes and to the diabetes-accelerating effects of polyinosinic-polycytidylic acid injections. These results suggest that the presence of environmental viral pathogens may act to inhibit effector cell function in lymphopenic DP rats while enhancing effector cell activity in nonlymphopenic DR rats.

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Year:  1991        PMID： 1899407     DOI： 10.2337/diab.40.2.259

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  26 in total

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5.  Natural killer cell depletion and diabetes mellitus in the BB/Wor rat (revisited).

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7.  Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat.

Authors:  A K Barlow; A A Like
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9.  Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies.

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10.  Lymphocyte subset abnormalities, autoantibodies and their relationship with HLA DR types in children with type 1 (insulin-dependent) diabetes and their first degree relatives.

Authors:  M Peakman; T Warnock; A Vats; G L McNab; J Underhill; P T Donaldson; D Vergani
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