Literature DB >> 1899342

Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain.

S Ueno1, K Kotani, A Sano, Y Kakimoto.   

Abstract

A unique dipeptide was isolated from bovine brain using five steps of ion-exchange chromatography. Its acid hydrolysate contained equimolar amounts of beta-alanine and hypusine. The structure of the peptide was elucidated as alpha-(beta-alanyl)hypusine using dansylation technique. About 1 mumol of the compound was isolated from 1090 g of bovine brain.

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Year:  1991        PMID： 1899342     DOI： 10.1016/0304-4165(91)90209-y

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation.

Authors:  M H Park; Y A Joe; K R Kang; Y B Lee; E C Wolff
Journal:  Amino Acids       Date:  1996-06       Impact factor: 3.520

2.  Specific and sensitive GC-MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study.

Authors:  Svetlana Baskal; Annette Kaiser; Catharina Mels; Ruan Kruger; Dimitrios Tsikas
Journal:  Amino Acids       Date:  2022-03-03       Impact factor: 3.789
  2 in total

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