| Literature DB >> 18992833 |
Sun-Young Ju1, Kyung-Ah Cho, Su Jin Cho, Yun-Jae Jung, So-Youn Woo, Ju-Young Seoh, Ho-Seong Han, Kyung-Ha Ryu.
Abstract
Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1alpha was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl(4)-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged liver.Entities:
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Year: 2008 PMID： 18992833 DOI： 10.1016/j.cellbi.2008.10.002
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612