Literature DB >> 18991115

Detecting outliers in multivariate laboratory data.

Harry Southworth1.   

Abstract

Laboratory data collected in clinical trials often include outliers, and these are often the observations of most interest. In high dimensional settings, outliers can be difficult to detect and can be masked by classical statistical methods. A method of plotting robustly scaled data in such a way as to expose outliers is described and an application is presented.

Mesh:

Year:  2008        PMID: 18991115     DOI: 10.1080/10543400802369046

Source DB:  PubMed          Journal:  J Biopharm Stat        ISSN: 1054-3406            Impact factor:   1.051


  4 in total

1.  Validation of multivariate outlier detection analyses used to identify potential drug-induced liver injury in clinical trial populations.

Authors:  Xiwu Lin; Daniel Parks; Jeffery Painter; Christine M Hunt; Heide A Stirnadel-Farrant; Jie Cheng; Alan Menius; Kwan Lee
Journal:  Drug Saf       Date:  2012-10-01       Impact factor: 5.606

Review 2.  Methodology to assess clinical liver safety data.

Authors:  Michael Merz; Kwan R Lee; Gerd A Kullak-Ublick; Andreas Brueckner; Paul B Watkins
Journal:  Drug Saf       Date:  2014-11       Impact factor: 5.606

Review 3.  Statistical methods for the analysis of adverse event data in randomised controlled trials: a scoping review and taxonomy.

Authors:  Rachel Phillips; Odile Sauzet; Victoria Cornelius
Journal:  BMC Med Res Methodol       Date:  2020-11-30       Impact factor: 4.615

4.  Understanding current practice, identifying barriers and exploring priorities for adverse event analysis in randomised controlled trials: an online, cross-sectional survey of statisticians from academia and industry.

Authors:  Rachel Phillips; Victoria Cornelius
Journal:  BMJ Open       Date:  2020-06-11       Impact factor: 2.692

  4 in total

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