OBJECTIVES: The Cancer of RESpiratory Tract (CREST) biorepository was established to investigate biological mechanisms and to develop tools and strategies for primary and secondary prevention of respiratory tract cancer. The CREST biorepository is focused on pleural malignant mesothelioma, a rare and severe cancer linked to asbestos exposure whose incidence is particularly high in the Ligurian region. METHODS: The CREST biorepository includes biological specimens from (a) patients with pleural malignant mesothelioma and lung cancer, (b) patients with nonneoplastic respiratory conditions, and (c) control subjects. Whole blood, plasma, serum, lymphocytes, pleural fluid, saliva, and biopsies are collected, and a questionnaire is administered. Collection, transportation, and storage are done according to international standards. RESULTS: As of January 31, 2008, the overall number of subjects recruited was 1,590 (446 lung cancer, 209 pleural malignant mesothelioma, and 935 controls). The biorepository includes a total of 10,055 aliquots (4,741 serum; 3,082 plasma; 1,599 whole blood; 633 pleural fluid; and 561 lymphocytes) and 107 biopsies. Demographic, clinical, and epidemiologic information is collected for each subject and processed in a dedicated database. CONCLUSIONS: The CREST biorepository is a valuable tool for molecular epidemiology and translational studies. This structure relies on a network of contacts with local health districts that allows for an active search for patients. This is a particularly efficient approach, especially when the object of the study is a rare cancer type. The CREST experience suggests that the presence of limited resources can be overcome by the biorepository specialization, the high quality of the epidemiologic information, and the variety of samples.
OBJECTIVES: The Cancer of RESpiratory Tract (CREST) biorepository was established to investigate biological mechanisms and to develop tools and strategies for primary and secondary prevention of respiratory tract cancer. The CREST biorepository is focused on pleural malignant mesothelioma, a rare and severe cancer linked to asbestos exposure whose incidence is particularly high in the Ligurian region. METHODS: The CREST biorepository includes biological specimens from (a) patients with pleural malignant mesothelioma and lung cancer, (b) patients with nonneoplastic respiratory conditions, and (c) control subjects. Whole blood, plasma, serum, lymphocytes, pleural fluid, saliva, and biopsies are collected, and a questionnaire is administered. Collection, transportation, and storage are done according to international standards. RESULTS: As of January 31, 2008, the overall number of subjects recruited was 1,590 (446 lung cancer, 209 pleural malignant mesothelioma, and 935 controls). The biorepository includes a total of 10,055 aliquots (4,741 serum; 3,082 plasma; 1,599 whole blood; 633 pleural fluid; and 561 lymphocytes) and 107 biopsies. Demographic, clinical, and epidemiologic information is collected for each subject and processed in a dedicated database. CONCLUSIONS: The CREST biorepository is a valuable tool for molecular epidemiology and translational studies. This structure relies on a network of contacts with local health districts that allows for an active search for patients. This is a particularly efficient approach, especially when the object of the study is a rare cancer type. The CREST experience suggests that the presence of limited resources can be overcome by the biorepository specialization, the high quality of the epidemiologic information, and the variety of samples.
Authors: Michele L Coté; Mei Liu; Stefano Bonassi; Monica Neri; Ann G Schwartz; David C Christiani; Margaret R Spitz; Joshua E Muscat; Gad Rennert; Katja K Aben; Angeline S Andrew; Vladimir Bencko; Heike Bickeböller; Paolo Boffetta; Paul Brennan; Hermann Brenner; Eric J Duell; Eleonora Fabianova; John K Field; Lenka Foretova; Søren Friis; Curtis C Harris; Ivana Holcatova; Yun-Chul Hong; Dolores Isla; Vladimir Janout; Lambertus A Kiemeney; Chikako Kiyohara; Qing Lan; Philip Lazarus; Jolanta Lissowska; Loic Le Marchand; Dana Mates; Keitaro Matsuo; Jose I Mayordomo; John R McLaughlin; Hal Morgenstern; Heiko Müeller; Irene Orlow; Bernard J Park; Mila Pinchev; Olaide Y Raji; Hedy S Rennert; Peter Rudnai; Adeline Seow; Isabelle Stucker; Neonila Szeszenia-Dabrowska; M Dawn Teare; Anne Tjønnelan; Donatella Ugolini; Henricus F M van der Heijden; Erich Wichmann; John K Wiencke; Penella J Woll; Ping Yang; David Zaridze; Zuo-Feng Zhang; Carol J Etzel; Rayjean J Hung Journal: Eur J Cancer Date: 2012-03-19 Impact factor: 9.162
Authors: Albert Rosenberger; Heike Bickeböller; Valerie McCormack; Darren R Brenner; Eric J Duell; Anne Tjønneland; Soren Friis; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Joachim Heinrich; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Vladimir Janout; Vladimir Bencko; Paul Brennan; Dana Mates; Ann G Schwartz; Michele L Cote; Zuo-Feng Zhang; Hal Morgenstern; Sam S Oh; John K Field; Olaide Raji; John R McLaughlin; John Wiencke; Loic LeMarchand; Monica Neri; Stefano Bonassi; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Paolo Boffetta; Rayjean J Hung Journal: Carcinogenesis Date: 2011-12-22 Impact factor: 4.944
Authors: Rayjean J Hung; Margaret R Spitz; Richard S Houlston; Ann G Schwartz; John K Field; Jun Ying; Yafang Li; Younghun Han; Xuemei Ji; Wei Chen; Xifeng Wu; Ivan P Gorlov; Jie Na; Mariza de Andrade; Geoffrey Liu; Yonathan Brhane; Nancy Diao; Angela Wenzlaff; Michael P A Davies; Triantafillos Liloglou; Maria Timofeeva; Thomas Muley; Hedy Rennert; Walid Saliba; Bríd M Ryan; Elise Bowman; Juan-Miguel Barros-Dios; Mónica Pérez-Ríos; Hal Morgenstern; Shanbeh Zienolddiny; Vidar Skaug; Donatella Ugolini; Stefano Bonassi; Erik H F M van der Heijden; Adonina Tardon; Stig E Bojesen; Maria Teresa Landi; Mattias Johansson; Heike Bickeböller; Susanne Arnold; Loic Le Marchand; Olle Melander; Angeline Andrew; Kjell Grankvist; Neil Caporaso; M Dawn Teare; Matthew B Schabath; Melinda C Aldrich; Lambertus A Kiemeney; H-Erich Wichmann; Philip Lazarus; Jose Mayordomo; Monica Neri; Aage Haugen; Zuo-Feng Zhang; Alberto Ruano-Raviña; Hermann Brenner; Curtis C Harris; Irene Orlow; Gadi Rennert; Angela Risch; Paul Brennan; David C Christiani; Christopher I Amos; Ping Yang; Olga Y Gorlova Journal: J Thorac Oncol Date: 2019-04-19 Impact factor: 15.609
Authors: Stephen A Krawetz; Peter R Casson; Michael P Diamond; Heping Zhang; Richard S Legro; William D Schlaff; Christos Coutifaris; Robert G Brzyski; Gregory M Christman; Nanette Santoro; Esther Eisenberg Journal: Syst Biol Reprod Med Date: 2011-09-07 Impact factor: 3.061
Authors: Darren R Brenner; Paolo Boffetta; Eric J Duell; Heike Bickeböller; Albert Rosenberger; Valerie McCormack; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Irene Brueske-Hohlfeld; Ann G Schwartz; Michele L Cote; Anne Tjønneland; Søren Friis; Loic Le Marchand; Zuo-Feng Zhang; Hal Morgenstern; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Lenka Foretova; Vladimir Janout; Vladimir Bencko; Miriam Schejbalova; Paul Brennan; Ioan N Mates; Philip Lazarus; John K Field; Olaide Raji; John R McLaughlin; Geoffrey Liu; John Wiencke; Monica Neri; Donatella Ugolini; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Rayjean J Hung Journal: Am J Epidemiol Date: 2012-09-17 Impact factor: 4.897
Authors: Claire H Kim; Yuan-Chin Amy Lee; Rayjean J Hung; Paolo Boffetta; Dong Xie; Jason A Wampfler; Michele L Cote; Shen-Chih Chang; Donatella Ugolini; Monica Neri; Loic Le Marchand; Ann G Schwartz; Hal Morgenstern; David C Christiani; Ping Yang; Zuo-Feng Zhang Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-10-26 Impact factor: 4.254
Authors: Giuseppe Matullo; Simonetta Guarrera; Marta Betti; Giovanni Fiorito; Daniela Ferrante; Floriana Voglino; Gemma Cadby; Cornelia Di Gaetano; Fabio Rosa; Alessia Russo; Ari Hirvonen; Elisabetta Casalone; Sara Tunesi; Marina Padoan; Mara Giordano; Anna Aspesi; Caterina Casadio; Francesco Ardissone; Enrico Ruffini; Pier Giacomo Betta; Roberta Libener; Roberto Guaschino; Ezio Piccolini; Monica Neri; Arthur W B Musk; Nicholas H de Klerk; Jennie Hui; John Beilby; Alan L James; Jenette Creaney; Bruce W Robinson; Sutapa Mukherjee; Lyle J Palmer; Dario Mirabelli; Donatella Ugolini; Stefano Bonassi; Corrado Magnani; Irma Dianzani Journal: PLoS One Date: 2013-04-23 Impact factor: 3.240