Literature DB >> 18990566

Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine.

Valentín Hornillos1, Eugenia Carrillo, Luis Rivas, Francisco Amat-Guerri, A Ulises Acuña.   

Abstract

Two general synthetic methods are described, by which the highly fluorescent and photostable BODIPY group can be inserted in and aligned with the alkyl backbone of linear lipids. These methods have been used to prepare strongly emitting analogues of the leishmanicidal drug miltefosine, in which the antiparasite activity in vitro of the original drug is preserved.

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Year:  2008        PMID： 18990566     DOI： 10.1016/j.bmcl.2008.10.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Combination oral therapy against Leishmania amazonensis infection in BALB/c mice using nanoassemblies made from amphiphilic antimony(V) complex incorporating miltefosine.

Authors:  Virgínia M Carregal; Juliane S Lanza; Daniel M Souza; Arshad Islam; Cynthia Demicheli; Ricardo T Fujiwara; Luis Rivas; Frédéric Frézard
Journal:  Parasitol Res       Date:  2019-08-10       Impact factor: 2.289

2.  Genomic Appraisal of the Multifactorial Basis for In Vitro Acquisition of Miltefosine Resistance in Leishmania donovani.

Authors:  P Vacchina; B Norris-Mullins; M A Abengózar; C G Viamontes; J Sarro; M T Stephens; M E Pfrender; L Rivas; M A Morales
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

3.  Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

Authors:  Christopher Fernandez-Prada; Isabel M Vincent; Marie-Christine Brotherton; Mathew Roberts; Gaétan Roy; Luis Rivas; Philippe Leprohon; Terry K Smith; Marc Ouellette
Journal:  PLoS Negl Trop Dis       Date:  2016-12-02

4.  A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani.

Authors:  P Vacchina; B Norris-Mullins; E S Carlson; M A Morales
Journal:  Parasit Vectors       Date:  2016-12-01       Impact factor: 3.876

5.  Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake.

Authors:  Caroline R Espada; Rubens M Magalhães; Mario C Cruz; Paulo R Machado; Albert Schriefer; Edgar M Carvalho; Valentín Hornillos; João M Alves; Angela K Cruz; Adriano C Coelho; Silvia R B Uliana
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-02-25       Impact factor: 4.077

6.  Fluorescent labeling of Acanthamoeba assessed in situ from corneal sectioned microscopy.

Authors:  Susana Marcos; Jose Requejo-Isidro; Jesus Merayo-Lloves; A Ulises Acuña; Valentin Hornillos; Eugenia Carrillo; Pablo Pérez-Merino; Susana Del Olmo-Aguado; Carmen Del Aguila; Francisco Amat-Guerri; Luis Rivas
Journal:  Biomed Opt Express       Date:  2012-09-12       Impact factor: 3.732

7.  Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism.

Authors:  Isabel M Vincent; Stefan Weidt; Luis Rivas; Karl Burgess; Terry K Smith; Marc Ouellette
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2013-12-05       Impact factor: 4.077

8.  Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

Authors:  Annelies Mondelaers; Maria P Sanchez-Cañete; Sarah Hendrickx; Eline Eberhardt; Raquel Garcia-Hernandez; Laurence Lachaud; James Cotton; Mandy Sanders; Bart Cuypers; Hideo Imamura; Jean-Claude Dujardin; Peter Delputte; Paul Cos; Guy Caljon; Francisco Gamarro; Santiago Castanys; Louis Maes
Journal:  PLoS One       Date:  2016-04-28       Impact factor: 3.240

9.  Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition.

Authors:  Zuzana Rubíková; Vadym Sulimenko; Tomáš Paulenda; Pavel Dráber
Journal:  Front Immunol       Date:  2018-07-09       Impact factor: 7.561

10.  Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection.

Authors:  Sarah Hendrickx; Lieselotte Van Bockstal; Dimitri Bulté; Annelies Mondelaers; Hamide Aslan; Luis Rivas; Louis Maes; Guy Caljon
Journal:  Parasit Vectors       Date:  2020-02-22       Impact factor: 3.876
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