BACKGROUND: Relationships between environment and cortical-limbic-striatal pathways are not well-researched in child bipolar I disorder (BP-I). METHODS: This was a controlled, blindly rated magnetic resonance imaging study of children with DSM-IV BP-I, manic or mixed type, compared with matched typically developing children (TC). RESULTS: There were 47 subjects (21 BP-I, 26 TC) aged 14.0+/-3.1 (BP-I onset age 8.8+/-4.2). Total intracranial volume was greater in male subjects (n=28) versus female subjects (n=19) [F(1,44)=24.3, p< .001], controlling for age. Volumes were not significantly different in BP-I and TC groups, after accounting for multiple comparisons, in the medial orbital frontal cortex, rostral anterior cingulate cortex, hippocampus, amygdala (AMG), or nucleus accumbens (NAcc). Across subjects (n=47), a greater number of independent life events (ILE) was associated with smaller AMG [F(1,36)=7.8, p= .009] and NAcc [F(1,36) = 9.4, p= .004] volumes, controlling for total intracranial volume (TICV), group, age, sex, and family psychopathology. Use of stimulant medication at the time of the scan was associated with larger AMG volume [F(1,41)=9.0, p= .005], controlling for TICV, group, age, and sex. In male subjects, the age x group interaction was a significant predictor in general linear models of AMG (p= .028) and NAcc (p= .030) volumes. Effects of low maternal warmth were not significant. CONCLUSIONS: Findings suggest that ILE affect AMG and NAcc volume, but further research is needed to examine specificity to child BP-I. Furthermore, differential age x group (child BP-I vs. TC) effects only in male subjects are consistent with differential brain development by sex.
BACKGROUND: Relationships between environment and cortical-limbic-striatal pathways are not well-researched in childbipolar I disorder (BP-I). METHODS: This was a controlled, blindly rated magnetic resonance imaging study of children with DSM-IV BP-I, manic or mixed type, compared with matched typically developing children (TC). RESULTS: There were 47 subjects (21 BP-I, 26 TC) aged 14.0+/-3.1 (BP-I onset age 8.8+/-4.2). Total intracranial volume was greater in male subjects (n=28) versus female subjects (n=19) [F(1,44)=24.3, p< .001], controlling for age. Volumes were not significantly different in BP-I and TC groups, after accounting for multiple comparisons, in the medial orbital frontal cortex, rostral anterior cingulate cortex, hippocampus, amygdala (AMG), or nucleus accumbens (NAcc). Across subjects (n=47), a greater number of independent life events (ILE) was associated with smaller AMG [F(1,36)=7.8, p= .009] and NAcc [F(1,36) = 9.4, p= .004] volumes, controlling for total intracranial volume (TICV), group, age, sex, and family psychopathology. Use of stimulant medication at the time of the scan was associated with larger AMG volume [F(1,41)=9.0, p= .005], controlling for TICV, group, age, and sex. In male subjects, the age x group interaction was a significant predictor in general linear models of AMG (p= .028) and NAcc (p= .030) volumes. Effects of low maternal warmth were not significant. CONCLUSIONS: Findings suggest that ILE affect AMG and NAcc volume, but further research is needed to examine specificity to childBP-I. Furthermore, differential age x group (childBP-I vs. TC) effects only in male subjects are consistent with differential brain development by sex.
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: J N Giedd; A C Vaituzis; S D Hamburger; N Lange; J C Rajapakse; D Kaysen; Y C Vauss; J L Rapoport Journal: J Comp Neurol Date: 1996-03-04 Impact factor: 3.215
Authors: Rhoshel K Lenroot; Nitin Gogtay; Deanna K Greenstein; Elizabeth Molloy Wells; Gregory L Wallace; Liv S Clasen; Jonathan D Blumenthal; Jason Lerch; Alex P Zijdenbos; Alan C Evans; Paul M Thompson; Jay N Giedd Journal: Neuroimage Date: 2007-04-06 Impact factor: 6.556
Authors: B Geller; K Bolhofner; J L Craney; M Williams; M P DelBello; K Gundersen Journal: J Am Acad Child Adolesc Psychiatry Date: 2000-12 Impact factor: 8.829
Authors: Robert M Post; Lori L Altshuler; Gabriele S Leverich; Willem A Nolen; Ralph Kupka; Heinz Grunze; Mark A Frye; Trisha Suppes; Susan L McElroy; Paul E Keck; Mike Rowe Journal: Prim Care Companion CNS Disord Date: 2014-12-18
Authors: Nicholas D Walsh; Tim Dalgleish; Michael V Lombardo; Valerie J Dunn; Anne-Laura Van Harmelen; Maria Ban; Ian M Goodyer Journal: Neuroimage Clin Date: 2014-01-11 Impact factor: 4.881