Literature DB >> 18989794

Study on the spatial architecture of p53, MDM2, and p14ARF containing complexes.

Andrej Savchenko1, Mariya Yurchenko, Boris Snopok, Elena Kashuba.   

Abstract

We have developed a surface plasmon resonance (SPR)-based immunocapture approach to study multimeric protein-protein complexes. A composition and spatial architecture of protein complexes that contained GST-tagged p53, p14ARF, and MDM2 was examined by the developed approach. Obtained results verified that the p53 protein possesses two binding sites for MDM2. Ternary complexes containing p14ARF, MDM2, and p53 proteins could only be formed when MDM2 protein functions as a bridging molecule. That was confirmed by immunoprecipitation and immunostaining.

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Year:  2008        PMID： 18989794     DOI： 10.1007/s12033-008-9116-x

Source DB:  PubMed          Journal:  Mol Biotechnol        ISSN： 1073-6085            Impact factor:   2.695


  26 in total

Review 1.  Structure and function in the p53 family.

Authors:  C H Arrowsmith
Journal:  Cell Death Differ       Date:  1999-12       Impact factor: 15.828

Review 2.  The MDM2-p53 interaction.

Authors:  Ute M Moll; Oleksi Petrenko
Journal:  Mol Cancer Res       Date:  2003-12       Impact factor: 5.852

3.  Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

Authors:  B Vojtesek; H Dolezalova; L Lauerova; M Svitakova; P Havlis; J Kovarik; C A Midgley; D P Lane
Journal:  Oncogene       Date:  1995-01-19       Impact factor: 9.867

4.  Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function.

Authors:  Chandrashekhar Korgaonkar; Jussara Hagen; Van Tompkins; April A Frazier; Chantal Allamargot; Frederick W Quelle; Dawn E Quelle
Journal:  Mol Cell Biol       Date:  2005-02       Impact factor: 4.272

Review 5.  The role of tetramerization in p53 function.

Authors:  P Chène
Journal:  Oncogene       Date:  2001-05-10       Impact factor: 9.867

Review 6.  Decision making by p53: life, death and cancer.

Authors:  M Oren
Journal:  Cell Death Differ       Date:  2003-04       Impact factor: 15.828

7.  SPR-based immunocapture approach to creating an interfacial sensing architecture: Mapping of the MRS18-2 binding site on retinoblastoma protein.

Authors:  Boris Snopok; Mariya Yurchenko; Laszlo Szekely; George Klein; Elena Kashuba
Journal:  Anal Bioanal Chem       Date:  2006-11-04       Impact factor: 4.142

8.  A novel p16INK4A transcript.

Authors:  L Mao; A Merlo; G Bedi; G I Shapiro; C D Edwards; B J Rollins; D Sidransky
Journal:  Cancer Res       Date:  1995-07-15       Impact factor: 12.701

9.  EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells.

Authors:  Elena Kashuba; Karin Mattsson; Katja Pokrovskaja; Csaba Kiss; Marina Protopopova; Barbro Ehlin-Henriksson; George Klein; Laszlo Szekely
Journal:  Int J Cancer       Date:  2003-07-10       Impact factor: 7.396

10.  Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV.

Authors:  K Lim; J X Ho; K Keeling; G L Gilliland; X Ji; F Rüker; D C Carter
Journal:  Protein Sci       Date:  1994-12       Impact factor: 6.725
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  2 in total

1.  Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.

Authors:  Ingunn W Jolma; Xiao Yu Ni; Ludger Rensing; Peter Ruoff
Journal:  Biophys J       Date:  2010-03-03       Impact factor: 4.033

Review 2.  Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network.

Authors:  Ilaria Moscetti; Salvatore Cannistraro; Anna Rita Bizzarri
Journal:  Sensors (Basel)       Date:  2017-11-20       Impact factor: 3.576
  2 in total

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