Literature DB >> 18989280

Graft-versus-host disease: suppression by statins.

Raewyn Broady1, Megan K Levings.   

Abstract

Two big challenges of transplantation biology are controlling the reaction of the graft to the host after hematopoietic stem cell transplantation and preventing rejection of donor organs by the host. Raewyn Broady and Megan K. Levings discuss the first challenge, examining studies suggesting that statins might be helpful to control graft-versus-host disease. Kathryn Wood tackles the second challenge in the context of the 'Edmonton protocol', a procedure that can restore the ability to control blood glucose in people with type 1 diabetes--but only in the short term.

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Year:  2008        PMID: 18989280     DOI: 10.1038/nm1108-1155

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  19 in total

1.  Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model.

Authors:  Rupal Pandey; Venkatesh L Hegde; Mitzi Nagarkatti; Prakash S Nagarkatti
Journal:  J Pharmacol Exp Ther       Date:  2011-06-14       Impact factor: 4.030

2.  Impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation.

Authors:  Marcello Rotta; Barry E Storer; Rainer Storb; Paul J Martin; Mary E D Flowers; Miwa S Vernon; Amanda Peffer; David G Maloney; H Joachim Deeg; Brenda M Sandmaier; Frederick R Appelbaum; Marco Mielcarek
Journal:  Biol Blood Marrow Transplant       Date:  2010-05-26       Impact factor: 5.742

Review 3.  Immune modulatory effects of statins.

Authors:  Robert Zeiser
Journal:  Immunology       Date:  2018-02-20       Impact factor: 7.397

4.  Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice.

Authors:  Talles Prosperi de Paula; Patrícia Campi Santos; Raquel Duque do Nascimento Arifa; Angélica T Vieira; Ludmila de Matos Baltazar; Thiago Vinícius Ávila; Caio Tavares Fagundes; Zélia Menezes Garcia; Renata Lacerda Lima; Mauro Martins Teixeira; Danielle G Souza
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

5.  The association between donor and recipient statin use and infections after allogeneic hematopoietic cell transplantation.

Authors:  S Seo; M Boeckh; B E Storer; M M Schubert; M Rotta; B M Sandmaier; M Mielcarek
Journal:  Bone Marrow Transplant       Date:  2015-01-19       Impact factor: 5.483

6.  Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation.

Authors:  Marcello Rotta; Barry E Storer; Rainer F Storb; Paul J Martin; Shelly Heimfeld; Amanda Peffer; David G Maloney; H Joachim Deeg; Brenda M Sandmaier; Frederick R Appelbaum; Marco Mielcarek
Journal:  Blood       Date:  2009-12-04       Impact factor: 22.113

Review 7.  Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis.

Authors:  Linda Björkhem-Bergman; Peter Bergman; Jan Andersson; Jonatan D Lindh
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

8.  Atorvastatin for the Prophylaxis of Acute Graft-versus-Host Disease in Patients Undergoing HLA-Matched Related Donor Allogeneic Hematopoietic Stem Cell Transplantation (allo-HCT).

Authors:  Yvonne A Efebera; Susan Geyer; Leslie Andritsos; Sumithira Vasu; Samantha Jaglowski; Anissa Bingman; William Blum; Rebecca Klisovic; Craig C Hofmeister; Don M Benson; Sam Penza; Patrick Elder; Katie Cortright; Rhonda Kitzler; Kevin Coombes; Lynn O'Donnell; Beth Daneault; Hillary Bradbury; Jianying Zhang; Xilin Chen; Sabrina Garman; Parvathi Ranganathan; Xueyan Yu; Jessica Hofstetter; Jianhua Yu; Ramiro Garzon; Scott R Scrape; Gerard Lozanski; Steven M Devine
Journal:  Biol Blood Marrow Transplant       Date:  2015-08-06       Impact factor: 5.742

9.  High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statin therapy.

Authors:  Sascha Dietrich; Jürgen G Okun; Kathrin Schmidt; Christine S Falk; Andreas H Wagner; Suzan Karamustafa; Aleksandar Radujkovic; Ute Hegenbart; Anthony D Ho; Peter Dreger; Thomas Luft
Journal:  Haematologica       Date:  2013-10-18       Impact factor: 9.941

10.  Sibling donor and recipient immune modulation with atorvastatin for the prophylaxis of acute graft-versus-host disease.

Authors:  Mehdi Hamadani; Laura F Gibson; Scot C Remick; Sijin Wen; William Petros; William Tse; Kathleen M Brundage; Jeffrey A Vos; Aaron Cumpston; Pamela Bunner; Michael D Craig
Journal:  J Clin Oncol       Date:  2013-10-28       Impact factor: 44.544

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