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Literature DB >> 1898925

Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans.

Abstract

Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidation to melanin. Catecholamine metabolism appears to protect C. neoformans from oxidants.

Entities: Chemical Disease Species

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Year: 1991 PMID： 1898925 PMCID： PMC207201 DOI： 10.1128/jb.173.1.401-403.1991

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

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Authors: E S Jacobson
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Review 2. Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.

Authors: Tricia A Missall; Jennifer K Lodge; Joan E McEwen
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Review 3. Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds.

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Journal: Infect Immun Date: 1999-01 Impact factor: 3.441

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Authors: L Liu; K Wakamatsu; S Ito; P R Williamson
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