Literature DB >> 18988836

Consciousness and anesthesia.

Michael T Alkire1, Anthony G Hudetz, Giulio Tononi.   

Abstract

When we are anesthetized, we expect consciousness to vanish. But does it always? Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to which it causes unconsciousness is harder to establish. For instance, certain anesthetics act on areas of the brain's cortex near the midline and abolish behavioral responsiveness, but not necessarily consciousness. Unconsciousness is likely to ensue when a complex of brain regions in the posterior parietal area is inactivated. Consciousness vanishes when anesthetics produce functional disconnection in this posterior complex, interrupting cortical communication and causing a loss of integration; or when they lead to bistable, stereotypic responses, causing a loss of information capacity. Thus, anesthetics seem to cause unconsciousness when they block the brain's ability to integrate information.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18988836      PMCID: PMC2743249          DOI: 10.1126/science.1149213

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  63 in total

1.  Projections from cortex to cephalic brain stem (reticular formation) in monkey.

Authors:  J D FRENCH; R HERNANDEZ-PEON; R B LIVINGSTON
Journal:  J Neurophysiol       Date:  1955-01       Impact factor: 2.714

2.  In vivo imaging of human limbic responses to nitrous oxide inhalation.

Authors:  F E Gyulai; L L Firestone; M A Mintun; P M Winter
Journal:  Anesth Analg       Date:  1996-08       Impact factor: 5.108

3.  Mechanism of anesthesia revealed by shunting actions of isoflurane on thalamocortical neurons.

Authors:  C R Ries; E Puil
Journal:  J Neurophysiol       Date:  1999-04       Impact factor: 2.714

4.  A measure of consciousness and memory during isoflurane administration: the coherent frequency.

Authors:  R Munglani; J Andrade; D J Sapsford; A Baddeley; J G Jones
Journal:  Br J Anaesth       Date:  1993-11       Impact factor: 9.166

Review 5.  Central neuronal pathways and the process of anaesthesia.

Authors:  A Angel
Journal:  Br J Anaesth       Date:  1993-07       Impact factor: 9.166

6.  Absence of memory for intraoperative information during surgery under adequate general anaesthesia.

Authors:  I F Russell; M Wang
Journal:  Br J Anaesth       Date:  1997-01       Impact factor: 9.166

7.  Characterization of GABAergic seizure regulation in the midline thalamus.

Authors:  J W Miller; J A Ferrendelli
Journal:  Neuropharmacology       Date:  1990-07       Impact factor: 5.250

8.  The experience of complete neuromuscular blockade in awake humans.

Authors:  G P Topulos; R W Lansing; R B Banzett
Journal:  J Clin Anesth       Date:  1993 Sep-Oct       Impact factor: 9.452

9.  Subanesthetic doses of ketamine, diazepam, and nitrous oxide for adult outpatient sedation.

Authors:  M R Tucker; J R Hann; C L Phillips
Journal:  J Oral Maxillofac Surg       Date:  1984-10       Impact factor: 1.895

10.  Mapping the structural core of human cerebral cortex.

Authors:  Patric Hagmann; Leila Cammoun; Xavier Gigandet; Reto Meuli; Christopher J Honey; Van J Wedeen; Olaf Sporns
Journal:  PLoS Biol       Date:  2008-07-01       Impact factor: 8.029

View more
  377 in total

1.  In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice.

Authors:  Kevin C Stieger; James R Eles; Kip A Ludwig; Takashi D Y Kozai
Journal:  J Neurosci Res       Date:  2020-06-26       Impact factor: 4.164

2.  Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics.

Authors:  Jeremy Pick; Yihan Chen; Jason T Moore; Yi Sun; Abraham J Wyner; Eliot B Friedman; Max B Kelz
Journal:  Anesthesiology       Date:  2011-10       Impact factor: 7.892

3.  Propofol disrupts functional interactions between sensory and high-order processing of auditory verbal memory.

Authors:  Xiaolin Liu; Kathryn K Lauer; Barney D Ward; Stephen M Rao; Shi-Jiang Li; Anthony G Hudetz
Journal:  Hum Brain Mapp       Date:  2011-09-20       Impact factor: 5.038

Review 4.  General anesthesia and altered states of arousal: a systems neuroscience analysis.

Authors:  Emery N Brown; Patrick L Purdon; Christa J Van Dort
Journal:  Annu Rev Neurosci       Date:  2011       Impact factor: 12.449

5.  Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons.

Authors:  Hsiao-Ying Wey; Danny J Wang; Timothy Q Duong
Journal:  J Cereb Blood Flow Metab       Date:  2010-09-08       Impact factor: 6.200

6.  The effect of skin incision on the electroencephalogram during general anesthesia maintained with propofol or desflurane.

Authors:  James W Sleigh; Kate Leslie; Logan Voss
Journal:  J Clin Monit Comput       Date:  2010-08-01       Impact factor: 2.502

7.  Mechanisms of Spatiotemporal Selectivity in Cortical Area MT.

Authors:  Ambarish S Pawar; Sergei Gepshtein; Sergey Savel'ev; Thomas D Albright
Journal:  Neuron       Date:  2018-12-31       Impact factor: 17.173

8.  Auditory responses and stimulus-specific adaptation in rat auditory cortex are preserved across NREM and REM sleep.

Authors:  Yuval Nir; Vladyslav V Vyazovskiy; Chiara Cirelli; Matthew I Banks; Giulio Tononi
Journal:  Cereb Cortex       Date:  2013-12-08       Impact factor: 5.357

9.  Individualized Thalamic Parcellation Reveals Alterations in Shape and Microstructure of Thalamic Nuclei in Patients with Disorder of Consciousness.

Authors:  Weihao Zheng; Xufei Tan; Tingting Liu; Xiaoxia Li; Jian Gao; Lirong Hong; Xiaotong Zhang; Zhiyong Zhao; Yamei Yu; Yi Zhang; Benyan Luo; Dan Wu
Journal:  Cereb Cortex Commun       Date:  2021-04-02

10.  Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects.

Authors:  Zachary T Irwin; Mohammad Z Awad; Christopher L Gonzalez; Arie Nakhmani; J Nicole Bentley; Thomas A Moore; Kenneth G Smithson; Barton L Guthrie; Harrison C Walker
Journal:  Clin Neurophysiol       Date:  2020-03-12       Impact factor: 3.708

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.