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Literature DB >> 18988188

Metastasis and AKT activation.

Shijie Sheng¹, Meng Qiao, Arthur B Pardee.

Abstract

Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti-metastasis therapies.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 18988188 DOI： 10.1002/jcp.21616

Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384

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Cited

38 in total

1. Many Roles of CCL20: Emphasis on Breast Cancer.

Authors: Kingsley O Osuala; Bonnie F Sloane
Journal: Postdoc J Date: 2014-03

2. Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation.

Authors: M Margarida Bernardo; Yonghong Meng; Jaron Lockett; Gregory Dyson; Alan Dombkowski; Alexander Kaplun; Xiaohua Li; Shuping Yin; Sijana Dzinic; Mary Olive; Ivory Dean; David Krass; Kamiar Moin; R Daniel Bonfil; Michael Cher; Wael Sakr; Shijie Sheng
Journal: Genes Cancer Date: 2011-11

3. Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.

Authors: Yingmei Wang; Da Yang; David Cogdell; Limei Hu; Fengxia Xue; Russell Broaddus; Wei Zhang
Journal: Technol Cancer Res Treat Date: 2010-04

4. BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

Authors: Supriya Gaitonde; Surya K De; Marianna Tcherpakov; Antimone Dewing; Hongbin Yuan; Megan Riel-Mehan; Stan Krajewski; Gavin Robertson; Maurizio Pellecchia; Ze'ev Ronai
Journal: Pigment Cell Melanoma Res Date: 2009-01-17 Impact factor: 4.693

5. RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion.

Authors: Rajeev K Boregowda; Oyenike O Olabisi; Walid Abushahba; Byeong-Seon Jeong; Keneshia K Haenssen; Wenjin Chen; Marina Chekmareva; Ahmed Lasfar; David J Foran; James S Goydos; Karine A Cohen-Solal
Journal: Cancer Lett Date: 2014-03-18 Impact factor: 8.679

Metastasis and AKT activation.

1. Many Roles of CCL20: Emphasis on Breast Cancer.

2. Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation.

3. Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.

4. BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

5. RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion.

6. Click hybridization of immune cells and polyamidoamine dendrimers.

7. The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.

8. Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.

Review 9. Cell survival and metastasis regulation by Akt signaling in colorectal cancer.

10. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction.