| Literature DB >> 18987831 |
Takuichiro Hide1, Tatsuya Takezaki, Hideo Nakamura, Junichi Kuratsu, Toru Kondo.
Abstract
Glioblastoma multiforme (GBM) is one of the most malignant forms of human cancer. Despite intensive treatment, the mean survival of GBM patients remains about 1 year. Recent cancer studies revealed that cancer tissues are pathologically heterogeneous and only a small population of cells has the specific ability to reinitiate cancer. This small cell population is called cancer stem cells (CSCs); in brain tumors these are known as brain tumor stem cells (BTSCs). The identification of BTSCs yielded new insights into chemo-and radioresistance, by which BTSCs can survive selectively and initiate recurrence. Research focused on BTSCs as treatment targets may contribute to the discovery of new therapeutic strategies.Entities:
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Year: 2008 PMID： 18987831 DOI： 10.1007/s10014-008-0237-5
Source DB: PubMed Journal: Brain Tumor Pathol ISSN： 1433-7398 Impact factor: 3.298