Literature DB >> 18987388

Regulation of macrophage function in inflammation and atherosclerosis.

Norihito Shibata1, Christopher K Glass.   

Abstract

Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis. This suggests that crosstalk between lipid metabolism and innate immunity pathways plays an important role for the development and/or the prevention of atherosclerosis. However, it is not fully defined how innate immunity affects lipid metabolism. Macrophages play a central role in atherogenesis through the accumulation of cholesterol and the production of inflammatory mediators and cytokines. Liver X receptors (LXRs) exert an important atheroprotective effect in the macrophage. In addition to regulating cholesterol metabolism, LXRs are also negative regulators of macrophage inflammatory gene responses. In this review, we will discuss the roles of LXRs in the macrophage as key factors that link innate immunity and lipid metabolism.

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Year:  2008        PMID： 18987388      PMCID： PMC2674700          DOI： 10.1194/jlr.R800063-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  48 in total

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  40 in total

1.  Tris-2(hydroxyethyl)ammonium (2-methylphenoxy)acetate as an inhibitor of synthesis of acid cholesterol esterase of platelets and mononuclear cells.

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Journal:  Dokl Biochem Biophys       Date:  2012-01-06       Impact factor: 0.788

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Authors:  Alessandro Venosa; Ley Cody Smith; Alexa Murray; Tanvi Banota; Andrew J Gow; Jeffrey D Laskin; Debra L Laskin
Journal:  Toxicol Sci       Date:  2019-12-01       Impact factor: 4.849

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Journal:  J Lipid Res       Date:  2013-06-17       Impact factor: 5.922

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Authors:  Ismail Sergin; Babak Razani
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