Literature DB >> 18986807

Semi-synthesis and biological activity of gamma-lactones analogs of camptothecin.

Mingzong Li1, Weidong Tang, Fuxing Zeng, Liguang Lou, Tianpa You.   

Abstract

A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity relationship (SAR) of these analogs was studied and discussed.

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Year:  2008        PMID： 18986807     DOI： 10.1016/j.bmcl.2008.10.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Perspectives on biologically active camptothecin derivatives.

Authors:  Ying-Qian Liu; Wen-Qun Li; Susan L Morris-Natschke; Keduo Qian; Liu Yang; Gao-Xiang Zhu; Xiao-Bing Wu; An-Liang Chen; Shao-Yong Zhang; Xiang Nan; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-03-21       Impact factor: 12.944

2.  Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug.

Authors:  Poorani Krishnan; Mariappan Rajan; Sharmilah Kumari; S Sakinah; Sivan Padma Priya; Fatin Amira; Lawal Danjuma; Mok Pooi Ling; Sharida Fakurazi; Palanisamy Arulselvan; Akon Higuchi; Ramitha Arumugam; Abdullah A Alarfaj; Murugan A Munusamy; Rukman Awang Hamat; Giovanni Benelli; Kadarkarai Murugan; S Suresh Kumar
Journal:  Sci Rep       Date:  2017-09-08       Impact factor: 4.379
  2 in total

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