Jan Bjørn Nielsen1, Per Sjøgren. 1. Palliativt Team, Regionshospitalet Herning, DK-7400 Herning. jbjn@dadlnet.dk
Abstract
UNLABELLED: Clonidine is an alpha2-adrenergic agonist with analgetic properties. Due to its side-effects, the drug is administered via the epidural or spinal route. A literature search yielded nine controlled studies on clonidine as a supplemental drug in the epidural or spinal treatment of cancer pain. These studies were systematically reviewed to evaluate the evidence of efficacy in patients with cancer pain. CONCLUSION: Despite weak evidence, clonidine may be a useful adjunct in epidural or spinal morphine therapy of cancer pain.
UNLABELLED: Clonidine is an alpha2-adrenergic agonist with analgetic properties. Due to its side-effects, the drug is administered via the epidural or spinal route. A literature search yielded nine controlled studies on clonidine as a supplemental drug in the epidural or spinal treatment of cancer pain. These studies were systematically reviewed to evaluate the evidence of efficacy in patients with cancer pain. CONCLUSION: Despite weak evidence, clonidine may be a useful adjunct in epidural or spinal morphine therapy of cancer pain.
Authors: E Tigka; A Kotsiou; T Saranteas; J Mourouzis; G Kostopanagiotou; C Tesseromatis Journal: Eur J Drug Metab Pharmacokinet Date: 2009 Jul-Sep Impact factor: 2.569