Literature DB >> 18985643

Stereocontrolled solid-phase synthesis of oligonucleoside H-phosphonates by an oxazaphospholidine approach.

Naoki Iwamoto1, Natsuhisa Oka, Terutoshi Sato, Takeshi Wada.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 18985643     DOI： 10.1002/anie.200804408

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


× No keyword cloud information.
  5 in total

1.  Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.

Authors:  Naoki Iwamoto; David C D Butler; Nenad Svrzikapa; Susovan Mohapatra; Ivan Zlatev; Dinah W Y Sah; Stephany M Standley; Genliang Lu; Luciano H Apponi; Maria Frank-Kamenetsky; Jason Jingxin Zhang; Chandra Vargeese; Gregory L Verdine
Journal:  Nat Biotechnol       Date:  2017-08-21       Impact factor: 54.908

Review 2.  Synthesis of DNA/RNA and their analogs via phosphoramidite and H-phosphonate chemistries.

Authors:  Subhadeep Roy; Marvin Caruthers
Journal:  Molecules       Date:  2013-11-18       Impact factor: 4.411

3.  Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species.

Authors:  Michael Byrne; Vinod Vathipadiekal; Luciano Apponi; Naoki Iwamoto; Pachamuthu Kandasamy; Kenneth Longo; Fangjun Liu; Richard Looby; Lauren Norwood; Anee Shah; Juili Dilip Shelke; Chikdu Shivalila; Hailin Yang; Yuan Yin; Lankai Guo; Keith Bowman; Chandra Vargeese
Journal:  Transl Vis Sci Technol       Date:  2021-01-12       Impact factor: 3.283

Review 4.  Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development Therapeutics.

Authors:  Juergen Scharner; Isabel Aznarez
Journal:  Mol Ther       Date:  2020-12-25       Impact factor: 11.454

5.  Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.

Authors:  Hartmut Jahns; Nate Taneja; Jennifer L S Willoughby; Masaaki Akabane-Nakata; Christopher R Brown; Tuyen Nguyen; Anna Bisbe; Shigeo Matsuda; Matt Hettinger; Rajar M Manoharan; Kallanthottathil G Rajeev; Martin A Maier; Ivan Zlatev; Klaus Charisse; Martin Egli; Muthiah Manoharan
Journal:  Nucleic Acids Res       Date:  2022-02-22       Impact factor: 16.971
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.