Literature DB >> 18985424

The role of SK calcium-dependent potassium currents in regulating the activity of deep cerebellar nucleus neurons: a dynamic clamp study.

Steven Si Feng1, Dieter Jaeger.   

Abstract

We used the method of dynamic current clamping to determine the properties and function of the SK calcium-dependent K(+) current in neurons of the deep cerebellar nuclei (DCN). As previously reported, block of SK current with apamin leads to bursting of DCN neurons and a steepening of the f-I curve. We show here that the properties of the slow spike afterhyperpolarization are fully controlled by SK current and we derive kinetic properties of this current that explain its action on DCN neurons. Overall, the SK current provides an effective mechanism to tune the regularity of spiking and the f-I curve of DCN neurons.

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Year:  2008        PMID： 18985424     DOI： 10.1007/s12311-008-0077-1

Source DB:  PubMed          Journal:  Cerebellum        ISSN： 1473-4222            Impact factor:   3.847


  9 in total

1.  The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition.

Authors:  V Gauck; D Jaeger
Journal:  J Neurosci       Date:  2000-04-15       Impact factor: 6.167

2.  Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells.

Authors:  Mark Teagarden; Jeremy F Atherton; Mark D Bevan; Charles J Wilson
Journal:  J Physiol       Date:  2007-12-06       Impact factor: 5.182

3.  Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats.

Authors:  Karina Alviña; Kamran Khodakhah
Journal:  J Physiol       Date:  2008-03-27       Impact factor: 5.182

4.  Two pathways for the activation of small-conductance potassium channels in neurons of substantia nigra pars reticulata.

Authors:  Y Yanovsky; W Zhang; U Misgeld
Journal:  Neuroscience       Date:  2005-10-03       Impact factor: 3.590

5.  Mechanism of calcium gating in small-conductance calcium-activated potassium channels.

Authors:  X M Xia; B Fakler; A Rivard; G Wayman; T Johnson-Pais; J E Keen; T Ishii; B Hirschberg; C T Bond; S Lutsenko; J Maylie; J P Adelman
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6.  Ionic mechanisms underlying autonomous action potential generation in the somata and dendrites of GABAergic substantia nigra pars reticulata neurons in vitro.

Authors:  Jeremy F Atherton; Mark D Bevan
Journal:  J Neurosci       Date:  2005-09-07       Impact factor: 6.167

7.  Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cells.

Authors:  Lia Forti; Elisabetta Cesana; Jonathan Mapelli; Egidio D'Angelo
Journal:  J Physiol       Date:  2006-05-11       Impact factor: 5.182

8.  Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons.

Authors:  Joshua A Goldberg; Charles J Wilson
Journal:  J Neurosci       Date:  2005-11-02       Impact factor: 6.167

9.  Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.

Authors:  C D Aizenman; D J Linden
Journal:  J Neurophysiol       Date:  1999-10       Impact factor: 2.714
  9 in total
  9 in total

Review 1.  Emerging therapies in Friedreich's ataxia.

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Journal:  Neurodegener Dis Manag       Date:  2016

2.  Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells.

Authors:  Jin Y Huang; Klaus M Stiefel; Dario A Protti
Journal:  J Vis Exp       Date:  2013-05-16       Impact factor: 1.355

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4.  Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources.

Authors:  Risa J Lin; Dieter Jaeger
Journal:  J Neurophysiol       Date:  2011-02-16       Impact factor: 2.714

5.  Dynamic clamp: alteration of response properties and creation of virtual realities in neurophysiology.

Authors:  Michael N Economo; Fernando R Fernandez; John A White
Journal:  J Neurosci       Date:  2010-02-17       Impact factor: 6.167

6.  Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.

Authors:  Steven Si Feng; Risa Lin; Volker Gauck; Dieter Jaeger
Journal:  Cerebellum       Date:  2013-10       Impact factor: 3.847

Review 7.  The cellular building blocks of breathing.

Authors:  J M Ramirez; A Doi; A J Garcia; F P Elsen; H Koch; A D Wei
Journal:  Compr Physiol       Date:  2012-10       Impact factor: 9.090

Review 8.  Rebound discharge in deep cerebellar nuclear neurons in vitro.

Authors:  Reza Tadayonnejad; Dustin Anderson; Michael L Molineux; W Hamish Mehaffey; Kusala Jayasuriya; Ray W Turner
Journal:  Cerebellum       Date:  2010-09       Impact factor: 3.847

9.  Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy.

Authors:  Lieke Kros; Sander Lindeman; Oscar H J Eelkman Rooda; Pavithra Murugesan; Lorenzo Bina; Laurens W J Bosman; Chris I De Zeeuw; Freek E Hoebeek
Journal:  Front Cell Neurosci       Date:  2017-10-31       Impact factor: 5.505
  9 in total

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