| Literature DB >> 18984163 |
Leigh Cuttell1, Andrew Vaughan, Elizabeth Silva, Claire J Escaron, Mark Lavine, Emeline Van Goethem, Jean-Pierre Eid, Magali Quirin, Nathalie C Franc.
Abstract
Phagocytosis is important during development and in the immune response for the removal of apoptotic cells and pathogens, yet its molecular mechanisms are poorly understood. In Caenorhabditis elegans, the CED2/5/10/12 pathway regulates actin during phagocytosis of apoptotic cells, whereas the role of the CED1/6/7 pathway in phagocytosis is unclear. We report that Undertaker (UTA), a Drosophila Junctophilin protein, is required for Draper (CED-1 homolog)-mediated phagocytosis. Junctophilins couple Ca2+ channels at the plasma membrane to those of the endoplasmic reticulum (ER), the Ryanodine receptors. We place Draper, its adaptor drCed-6, UTA, the Ryanodine receptor Rya-r44F, the ER Ca2+ sensor dSTIM, and the Ca2+-release-activated Ca2+ channel dOrai in the same pathway that promotes calcium homeostasis and phagocytosis. Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway.Entities:
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Year: 2008 PMID： 18984163 DOI： 10.1016/j.cell.2008.08.033
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582