D Willems1, F Wolff, F Mekahli, F Mekhali, C Gillet. 1. Clinical Chemistry and Diabetology Unit, Brugmann University Hospital, Brussels, Belgium. Dominique.willems@chu-brugmann.be
Abstract
OBJECTIVES: Evaluation of glomerular filtration rate is of crucial importance in diabetes. Cystatin C, a cysteine protease inhibitor seems to be an interesting parameter. DESIGN AND METHODS: 67 diabetic patients with normal creatinine are evaluated. Cystatin C is compared to renal markers, by reference to Cr EDTA clearance. RESULTS: Significant correlations are found between cystatin C and creatinine (r=0.54). GFR MDRD (r=-0.47) and GFR Cr EDTA (r=-0.47). The AUC of the receiver operating curves is better for GFR MDRD (0.83) and cystatin C (0.75) than for creatinine (0.63) considering the cut off value of 80 mL/min for GFR EDTA. CONCLUSION: Cystatin C seems to be a more sensitive parameter than creatinine for the detection of an incipient nephropathy in diabetes.
OBJECTIVES: Evaluation of glomerular filtration rate is of crucial importance in diabetes. Cystatin C, a cysteine protease inhibitor seems to be an interesting parameter. DESIGN AND METHODS: 67 diabeticpatients with normal creatinine are evaluated. Cystatin C is compared to renal markers, by reference to Cr EDTA clearance. RESULTS: Significant correlations are found between cystatin C and creatinine (r=0.54). GFR MDRD (r=-0.47) and GFR Cr EDTA (r=-0.47). The AUC of the receiver operating curves is better for GFR MDRD (0.83) and cystatin C (0.75) than for creatinine (0.63) considering the cut off value of 80 mL/min for GFR EDTA. CONCLUSION:Cystatin C seems to be a more sensitive parameter than creatinine for the detection of an incipient nephropathy in diabetes.
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