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Literature DB >> 1898348

Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.

A Fukamizu¹, T Hatae, Y Kon, M Sugimura, T Hasegawa, M Yokoyama, T Nomura, M Katsuki, K Murakami.

Abstract

To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.

Entities: Gene Species

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Year: 1991 PMID： 1898348 PMCID： PMC1151386 DOI： 10.1042/bj2780601

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice.

Authors: C D Sigmund; C A Jones; J R Fabian; J J Mullins; K W Gross
Journal: Biochem Biophys Res Commun Date: 1990-07-16 Impact factor: 3.575

Review 2. Germ-line transformation of mice.

Authors: R D Palmiter; R L Brinster
Journal: Annu Rev Genet Date: 1986 Impact factor: 16.830

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Authors: J P Camilleri; V N Phat; J Bariety; P Corvol; J Menard
Journal: J Histochem Cytochem Date: 1980-12 Impact factor: 2.479

4. Ren-1 and Ren-2 loci are expressed in mouse kidney.

Authors: L J Field; K W Gross
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

5. Detection and localization of renin messenger RNA in human pathologic tissues using in situ hybridization.

Authors: P Bruneval; J G Fournier; F Soubrier; M F Belair; J L Da Silva; C Guettier; F Pinet; I Tardivel; P Corvol; J Bariety
Journal: Am J Pathol Date: 1988-05 Impact factor: 4.307

6. Renin in the human kidney. Immunohistochemical localization.

Authors: M R Celio; T Inagami
Journal: Histochemistry Date: 1981

7. Tissue-specific expression of the human renin gene in transgenic mice.

Authors: A Fukamizu; M S Seo; T Hatae; M Yokoyama; T Nomura; M Katsuki; K Murakami
Journal: Biochem Biophys Res Commun Date: 1989-12-15 Impact factor: 3.575

8. Differential extra-renal expression of the mouse renin genes.

Authors: C C Miller; A T Carter; J I Brooks; R H Lovell-Badge; W J Brammar
Journal: Nucleic Acids Res Date: 1989-04-25 Impact factor: 16.971

9. Evolution of aspartyl proteases by gene duplication: the mouse renin gene is organized in two homologous clusters of four exons.

Authors: I Holm; R Ollo; J J Panthier; F Rougeon
Journal: EMBO J Date: 1984-03 Impact factor: 11.598

10. Regulated expression of the Ren-2 gene in transgenic mice derived from parental strains carrying only the Ren-1 gene.

Authors: D Tronik; M Dreyfus; C Babinet; F Rougeon
Journal: EMBO J Date: 1987-04 Impact factor: 11.598

4 in total