Literature DB >> 18983142

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.

Mark Seierstad1, J Guy Breitenbucher.   

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Year:  2008        PMID： 18983142     DOI： 10.1021/jm800311k

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  48 in total

1.  Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas.

Authors:  Giulia Palermo; Davide Branduardi; Matteo Masetti; Alessio Lodola; Marco Mor; Daniele Piomelli; Andrea Cavalli; Marco De Vivo
Journal:  J Med Chem       Date:  2011-09-08       Impact factor: 7.446

2.  Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.

Authors:  Douglas S Johnson; Eranthie Weerapana; Benjamin F Cravatt
Journal:  Future Med Chem       Date:  2010-06       Impact factor: 3.808

3.  Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

Authors:  Grzegorz Godlewski; Shakiru O Alapafuja; Sándor Bátkai; Spyros P Nikas; Resat Cinar; László Offertáler; Douglas Osei-Hyiaman; Jie Liu; Bani Mukhopadhyay; Judith Harvey-White; Joseph Tam; Karel Pacak; Jacqueline L Blankman; Benjamin F Cravatt; Alexandros Makriyannis; George Kunos
Journal:  Chem Biol       Date:  2010-11-24

4.  EMBM - a new enzyme mechanism-based method for rational design of chemical sites of covalent inhibitors.

Authors:  Tamar Traube; Subramaniam Vijayakumar; Michal Hirsch; Neta Uritsky; Michael Shokhen; Amnon Albeck
Journal:  J Chem Inf Model       Date:  2010-11-19       Impact factor: 4.956

5.  Lessons for fragment library design: analysis of output from multiple screening campaigns.

Authors:  I-Jen Chen; Roderick E Hubbard
Journal:  J Comput Aided Mol Des       Date:  2009-06-03       Impact factor: 3.686

6.  A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo.

Authors:  Jason R Clapper; Federica Vacondio; Alvin R King; Andrea Duranti; Andrea Tontini; Claudia Silva; Silvano Sanchini; Giorgio Tarzia; Marco Mor; Daniele Piomelli
Journal:  ChemMedChem       Date:  2009-09       Impact factor: 3.466

Review 7.  The endocannabinoid system and pain.

Authors:  Josée Guindon; Andrea G Hohmann
Journal:  CNS Neurol Disord Drug Targets       Date:  2009-12       Impact factor: 4.388

8.  Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

Authors:  Oscar Sasso; Rosalia Bertorelli; Tiziano Bandiera; Rita Scarpelli; Giampiero Colombano; Andrea Armirotti; Guillermo Moreno-Sanz; Angelo Reggiani; Daniele Piomelli
Journal:  Pharmacol Res       Date:  2012-03-07       Impact factor: 7.658

9.  Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.

Authors:  Katerina Otrubova; Monica Brown; Michael S McCormick; Gye W Han; Scott T O'Neal; Benjamin F Cravatt; Raymond C Stevens; Aron H Lichtman; Dale L Boger
Journal:  J Am Chem Soc       Date:  2013-04-12       Impact factor: 15.419

10.  Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.

Authors:  Alessio Lodola; Luigi Capoferri; Silvia Rivara; Giorgio Tarzia; Daniele Piomelli; Adrian Mulholland; Marco Mor
Journal:  J Med Chem       Date:  2013-03-07       Impact factor: 7.446
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