BACKGROUND: There are many indications for hepatic retransplantation. AIM: To identify factors influencing retransplantation needs and outcomes. PATIENTS AND METHODS: Retransplantation records from January 1993 to March 2005 were analysed. Patient and disease characteristics and survival outcomes for retransplantation were compared between various groups. RESULTS: Totally, 286 primary and 42 hepatic retransplantations were performed. Retransplantation indications included primary sclerosing cholangitis (PSC), primary biliary cirrhosis, chronic hepatitis C (HCV), chronic active hepatitis (CAH), and alcohol-related disease. Mean follow-up post-retransplantation was 31 +/- 9 months. Actuarial patient survival at 3 months, 1 year, 3 years, 5 years, and at the end of study was 71.4, 69, 59.5, 54.7, and 50%, respectively. Early and late retransplantation had 1-year survival of 73 and 68.5%, respectively. Retransplantation need was significantly higher for PSC, HCV, and CAH. CONCLUSIONS: Hepatic retransplantation remains a successful salvage option for transplant complications; however, its need is significantly influenced by the primary liver disease.
BACKGROUND: There are many indications for hepatic retransplantation. AIM: To identify factors influencing retransplantation needs and outcomes. PATIENTS AND METHODS: Retransplantation records from January 1993 to March 2005 were analysed. Patient and disease characteristics and survival outcomes for retransplantation were compared between various groups. RESULTS: Totally, 286 primary and 42 hepatic retransplantations were performed. Retransplantation indications included primary sclerosing cholangitis (PSC), primary biliary cirrhosis, chronic hepatitis C (HCV), chronic active hepatitis (CAH), and alcohol-related disease. Mean follow-up post-retransplantation was 31 +/- 9 months. Actuarial patient survival at 3 months, 1 year, 3 years, 5 years, and at the end of study was 71.4, 69, 59.5, 54.7, and 50%, respectively. Early and late retransplantation had 1-year survival of 73 and 68.5%, respectively. Retransplantation need was significantly higher for PSC, HCV, and CAH. CONCLUSIONS: Hepatic retransplantation remains a successful salvage option for transplant complications; however, its need is significantly influenced by the primary liver disease.
Authors: J C Magee; M L Barr; G P Basadonna; M R Johnson; S Mahadevan; M A McBride; D E Schaubel; A B Leichtman Journal: Am J Transplant Date: 2007 Impact factor: 8.086
Authors: R M Ghobrial; D G Farmer; A Baquerizo; S Colquhoun; H R Rosen; H Yersiz; J F Markmann; K E Drazan; C Holt; D Imagawa; L I Goldstein; P Martin; R W Busuttil Journal: Ann Surg Date: 1999-06 Impact factor: 12.969
Authors: W R Kim; R H Wiesner; J J Poterucha; T M Therneau; M Malinchoc; J T Benson; J S Crippin; G B Klintmalm; J Rakela; T E Starzl; R A Krom; R W Evans; E R Dickson Journal: Hepatology Date: 1999-08 Impact factor: 17.425
Authors: M Facciuto; D Heidt; J Guarrera; C A Bodian; C M Miller; S Emre; S R Guy; T M Fishbein; M E Schwartz; P A Sheiner Journal: Liver Transpl Date: 2000-03 Impact factor: 5.799
Authors: J F Markmann; J S Markowitz; H Yersiz; M Morrisey; D G Farmer; D A Farmer; J Goss; R Ghobrial; S V McDiarmid; R Stribling; P Martin; L I Goldstein; P Seu; C Shackleton; R W Busuttil Journal: Ann Surg Date: 1997-10 Impact factor: 12.969
Authors: Guy W Neff; Christopher B O'Brien; Jose Nery; Norah J Shire; Seigo Nishida; Julia delaGarza; Marzia Montalbano; Kamran Safdar; Phillip Ruiz; Eric Rideman; Jose A Gascon; Andreas G Tzakis; Juan Madariaga; Steven M Rudich Journal: Liver Transpl Date: 2004-12 Impact factor: 5.799
Authors: Renske Postma; Elizabeth B Haagsma; Paul M J G Peeters; Aad P van den Berg; Maarten J H Slooff Journal: Transpl Int Date: 2004-05-29 Impact factor: 3.782
Authors: Sasan Roayaie; Thomas D Schiano; Swan N Thung; Sukru H Emre; Thomas M Fishbein; Charles M Miller; Myron E Schwartz Journal: Hepatology Date: 2003-12 Impact factor: 17.425