OBJECTIVE: To compare the concentrations of cytokines belonging to Th17 axis (interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-gamma) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity. DESIGN: Cross-sectional study. SUBJECTS: Twenty-six obese women (age 20-52 years, body mass index (BMI): 30-48 kg/m(2)) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m(2)). MEASUREMENTS: Plasma levels of cytokines and leptin, BMI, waist circumference (WC) and insulin resistance index HOMA (homeostatic model assessment). RESULTS: Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-gamma, were higher in obese compared with lean women (P=0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r(s)=0.530), which was at the border of statistical significance (P=0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index. CONCLUSION: Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels.
OBJECTIVE: To compare the concentrations of cytokines belonging to Th17 axis (interleukin (IL)-17 and IL-23) and Th1 axis (IL-12 and interferon (IFN)-gamma) in obese and lean women, and to investigate their relationships with the proinflammatory adipokine leptin, proinflammatory cytokine macrophage migration inhibitory factor (MIF) and anthropometric and metabolic parameters of obesity. DESIGN: Cross-sectional study. SUBJECTS: Twenty-six obesewomen (age 20-52 years, body mass index (BMI): 30-48 kg/m(2)) and 20 healthy lean women (age 23-46 years, BMI: 18-25 kg/m(2)). MEASUREMENTS: Plasma levels of cytokines and leptin, BMI, waist circumference (WC) and insulin resistance index HOMA (homeostatic model assessment). RESULTS: Blood concentrations of IL-17, IL-23, MIF and leptin, but not IL-12 or IFN-gamma, were higher in obese compared with lean women (P=0.002, 0.046, 0.006 and 0.002, respectively). There was a positive correlation between IL-17 and IL-23 (r(s)=0.530), which was at the border of statistical significance (P=0.065). Neither IL-17 nor IL-23 correlated with leptin or MIF, and there was no association between IL-17 and IL-23 levels with BMI, WC or HOMA index. CONCLUSION:Interleukin-23/IL-17 axis is stimulated in obesewomen independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels.
Authors: Luis A Zúñiga; Wen-Jun Shen; Barbara Joyce-Shaikh; Ekaterina A Pyatnova; Andrew G Richards; Colin Thom; Sofia M Andrade; Daniel J Cua; Fredric B Kraemer; Eugene C Butcher Journal: J Immunol Date: 2010-10-29 Impact factor: 5.422
Authors: Tej Pratap Singh; Barbara Huettner; Harald Koefeler; Gerlinde Mayer; Isabella Bambach; Katrin Wallbrecht; Michael P Schön; Peter Wolf Journal: Am J Pathol Date: 2011-02 Impact factor: 4.307
Authors: Renuka Subramaniam; Hassan Aliakbarian; Hina Y Bhutta; David A Harris; Ali Tavakkoli; Eric G Sheu Journal: Obes Surg Date: 2019-12 Impact factor: 4.129
Authors: Laura J Edwards; Basil Sharrack; Azza Ismail; Christopher R Tench; Bruno Gran; Samish Dhungana; Johannes Brettschneider; Hayrettin Tumani; Cris S Constantinescu Journal: Am J Clin Exp Immunol Date: 2013-10-16
Authors: Minji Choi; Harmesh N Chaudhari; Young Rae Ji; Zae Young Ryoo; Sang Woo Kim; Jong Won Yun Journal: Mol Cell Biochem Date: 2015-06-06 Impact factor: 3.396