Literature DB >> 18981780

Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1.

Thor A Wagner1, Lisa M Frenkel.   

Abstract

CCR5 antagonists are approved for treatment-experienced individuals, who are at risk of harboring both drug-resistant and CXCR4-utilizing (X4) HIV-1. If CXCR4 usage and drug resistance are linked, CCR5 antagonists may select for CXCR4-utilizing viruses resistant to antiretrovirals. Analysis of 117 individual viruses found that 69% of CXCR4-utilizing viruses versus 48% of R5 viruses had drug resistance mutations (P = 0.025). Linkage of X4 and drug resistance may limit the effectiveness of CCR5 antagonists.

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Year:  2008        PMID： 18981780      PMCID： PMC2585823          DOI： 10.1097/QAD.0b013e328312c72c

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  5 in total

Review 1.  Predicting HIV-1 coreceptor usage with sequence analysis.

Authors:  Mark A Jensen; Angélique B van 't Wout
Journal:  AIDS Rev       Date:  2003 Apr-Jun       Impact factor: 2.500

Review 2.  Update of the drug resistance mutations in HIV-1: 2007.

Authors:  Victoria A Johnson; Françoise Brun-Vézinet; Bonaventura Clotet; Huldrych F Günthard; Daniel R Kuritzkes; Deenan Pillay; Jonathan M Schapiro; Douglas D Richman
Journal:  Top HIV Med       Date:  2007 Aug-Sep

3.  Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir.

Authors:  Mike Westby; Marilyn Lewis; Jeannette Whitcomb; Mike Youle; Anton L Pozniak; Ian T James; Tim M Jenkins; Manos Perros; Elna van der Ryst
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

4.  Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.

Authors:  Nicole H Tobin; Gerald H Learn; Sarah E Holte; Yang Wang; Ann J Melvin; Jennifer L McKernan; Diane M Pawluk; Kathleen M Mohan; Paul F Lewis; James I Mullins; Lisa M Frenkel
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

5.  Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy.

Authors:  Lisa M Frenkel; Yang Wang; Gerald H Learn; Jennifer L McKernan; Giovanina M Ellis; Kathleen M Mohan; Sarah E Holte; Shannon M De Vange; Diane M Pawluk; Ann J Melvin; Paul F Lewis; Laura M Heath; Ingrid A Beck; Madhumita Mahalanabis; Wilscott E Naugler; Nicole H Tobin; James I Mullins
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103
  5 in total
  6 in total

1.  Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.

Authors:  Binshan Shi; Christina Kitchen; Barbara Weiser; Douglas Mayers; Brian Foley; Kimdar Kemal; Kathryn Anastos; Marc Suchard; Monica Parker; Cheryl Brunner; Harold Burger
Journal:  Virology       Date:  2010-05-08       Impact factor: 3.616

2.  Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.

Authors:  Royce A Wilkinson; Seth H Pincus; Kejing Song; Joyce B Shepard; Alan J Weaver; Mohamed E Labib; Martin Teintze
Journal:  Bioorg Med Chem Lett       Date:  2013-01-30       Impact factor: 2.823

3.  Novel compounds containing multiple guanide groups that bind the HIV coreceptor CXCR4.

Authors:  Royce A Wilkinson; Seth H Pincus; Joyce B Shepard; Sarah K Walton; Edward P Bergin; Mohamed Labib; Martin Teintze
Journal:  Antimicrob Agents Chemother       Date:  2010-10-11       Impact factor: 5.191

4.  Phenotypic Coreceptor Tropism in Perinatally HIV-infected Youth Failing Antiretroviral Therapy.

Authors:  Allison L Agwu; Tzy-Jyun Yao; Susan H Eshleman; Kunjal Patel; Wei Huang; Sandra K Burchett; George K Siberry; Russell B Van Dyke
Journal:  Pediatr Infect Dis J       Date:  2016-07       Impact factor: 2.129

5.  Comparative analysis of cell culture and prediction algorithms for phenotyping of genetically diverse HIV-1 strains from Cameroon.

Authors:  Viswanath Ragupathy; Jiangqin Zhao; Xue Wang; Owen Wood; Sherwin Lee; Sherri Burda; Phillipe Nyambi; Indira Hewlett
Journal:  AIDS Res Ther       Date:  2009-11-25       Impact factor: 2.250

Review 6.  Development of peptide inhibitors of HIV transmission.

Authors:  Siyu Shi; Peter K Nguyen; Henry J Cabral; Ramon Diez-Barroso; Paul J Derry; Satoko M Kanahara; Vivek A Kumar
Journal:  Bioact Mater       Date:  2016-09-16
  6 in total

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