BACKGROUND: The main aim of the present study was to compare the occurrence of inflammatory cell infiltrates in the aorta, a vessel with a high occurrence of atherosclerosis, with that in the saphenous vein (SV) and internal mammary artery (IMA), which are protected from atherosclerosis. METHODS AND RESULTS: Samples from the aorta, SV, and IMA of 65 patients with inflammatory rheumatic diseases (IRD) and from 51 control patients undergoing coronary artery bypass graft surgery were examined for the presence and location of inflammatory cell infiltrates and atherosclerotic lesions. Mononuclear cell infiltrates (MCIs) in the media or adventitia were observed in 2% IMAs, 17% SVs, and 35% aortic specimens (SV vs IMA: p=0.006; SV vs aorta: p=0.001). Atherosclerotic lesions were present in none IMA, 3% SVs and 18% aortic specimens. IRD and smoking increased the odds of MCI in the aorta (odds ratio (OR)=3.6, 95% confidence interval (CI): 1.6-8.5 and OR=4.0, 95% CI: 1.5-10.9), but not in the SV or IMA. CONCLUSIONS: The occurrence of medial and adventitial MCI in the aorta, SV, and IMA paralleled each vessel's susceptibility to atherosclerosis: it was highest in the aorta and lowest in IMA. Local vascular inflammation may be involved in atherogenesis, and influence the patency of vascular grafts.
BACKGROUND: The main aim of the present study was to compare the occurrence of inflammatory cell infiltrates in the aorta, a vessel with a high occurrence of atherosclerosis, with that in the saphenous vein (SV) and internal mammary artery (IMA), which are protected from atherosclerosis. METHODS AND RESULTS: Samples from the aorta, SV, and IMA of 65 patients with inflammatory rheumatic diseases (IRD) and from 51 control patients undergoing coronary artery bypass graft surgery were examined for the presence and location of inflammatory cell infiltrates and atherosclerotic lesions. Mononuclear cell infiltrates (MCIs) in the media or adventitia were observed in 2% IMAs, 17% SVs, and 35% aortic specimens (SV vs IMA: p=0.006; SV vs aorta: p=0.001). Atherosclerotic lesions were present in none IMA, 3% SVs and 18% aortic specimens. IRD and smoking increased the odds of MCI in the aorta (odds ratio (OR)=3.6, 95% confidence interval (CI): 1.6-8.5 and OR=4.0, 95% CI: 1.5-10.9), but not in the SV or IMA. CONCLUSIONS: The occurrence of medial and adventitial MCI in the aorta, SV, and IMA paralleled each vessel's susceptibility to atherosclerosis: it was highest in the aorta and lowest in IMA. Local vascular inflammation may be involved in atherogenesis, and influence the patency of vascular grafts.
Authors: Tetsuo Horimatsu; Aaron S Patel; Rosaria Prasad; Lauren E Reid; Tyler W Benson; Abdalrahman Zarzour; Mourad Ogbi; Thiago Bruder do Nascimento; Eric Belin de Chantemele; Brian K Stansfield; Xin-Yun Lu; Ha Won Kim; Neal L Weintraub Journal: Cardiovasc Drugs Ther Date: 2018-10 Impact factor: 3.727
Authors: Luis P Roldan; Paola C Roldan; Wilmer L Sibbitt; Clifford R Qualls; Michelle D Ratliff; Carlos A Roldan Journal: Clin Rheumatol Date: 2020-10-06 Impact factor: 2.980
Authors: Kelly J Shields; Tom Eirik Mollnes; Jon Roger Eidet; Knut Mikkelsen; Sven M Almdahl; Barbara Bottazzi; Torstein Lyberg; Susan Manzi; Joseph M Ahearn; Ivana Hollan Journal: PLoS One Date: 2017-03-31 Impact factor: 3.240
Authors: Ammad Ahmed; Ivana Hollan; Samuel A Curran; Susan M Kitson; Marcello P Riggio; Knut Mikkelsen; Sven M Almdahl; Pål Aukrust; Iain B McInnes; Carl S Goodyear Journal: Arthritis Rheumatol Date: 2016-06 Impact factor: 10.995